CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow An erratum has been published
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gray, C.
Right arrow Articles by Mason, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gray, C.
Right arrow Articles by Mason, D.

Canadian Journal of Anesthesia, Vol 46, 957-961, Copyright © 1999 by Canadian Anesthesiologists' Society

ARTICLES

Target controlled infusion of ketamine as analgesia for TIVA with propofol

C Gray, CF Swinhoe, Y Myint and D Mason
Department of Surgical and Anaesthetic Sciences, University of Sheffield, Royal Hallamshire Hospital, United Kingdom. Cavin.Gray@Sheffield.ac.uk

PURPOSE: To determine the accuracy of a target controlled infusion system for ketamine and to assess its suitability for the provision of analgesia when used in conjunction with a propofol infusion in spontaneously breathing patients. METHODS: Nineteen, adult, ASA I-III patients scheduled for elective surgery were studied. After premedication with 20 mg temazepam an appropriate plasma concentration of ketamine was selected and, when the target controlled infusion (TCI) system indicated that this had been achieved, anesthesia was induced and maintained using a propofol infusion. The plasma ketamine concentration was measured at predetermined intervals and cardiovascular and respiratory parameters recorded at 10 min intervals. Patients were reviewed in recovery and 24 hr postoperatively to assess the adequacy of their recovery and the presence of any undesirable side effects. RESULTS: The TCI system had a median performance error against predicted plasma concentrations of 18.9% (SE 2.5%) and a median absolute performance error of 23.3% (SE 2.3%). Divergence was 20.3% (SE 30.1%) and wobble was 12.9% (SE 2.1%). There was a mean decrease in arterial pressure of 6.4% (SD 19.7%) and a mean increase in heart rate of 4.3% (SD 17.4%). Little respiratory depression occurred and all patients made a rapid postoperative recovery with none describing unpleasant dreams or hallucinations. CONCLUSION: The TCI system provided a clinically acceptable degree of control of the plasma ketamine concentration although some further improvement should be possible by amending the pharmacokinetic model. Clinically the combination with a propofol infusion proved to be a satisfactory anesthetic technique.


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
A. R. Absalom, M. Lee, D. K. Menon, S. R. Sharar, T. De Smet, J. Halliday, M. Ogden, P. Corlett, G. D. Honey, and P. C. Fletcher
Predictive performance of the Domino, Hijazi, and Clements models during low-dose target-controlled ketamine infusions in healthy volunteers
Br. J. Anaesth., May 1, 2007; 98(5): 615 - 623.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
M. White, P. de Graaff, B. Renshof, E. van Kan, and M. Dzoljic
Pharmacokinetics of S(+) ketamine derived from target controlled infusion
Br. J. Anaesth., March 1, 2006; 96(3): 330 - 334.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
R. R. Kennedy
The Effect of Using Different Values for the Effect-Site Equilibrium Half-Time on the Prediction of Effect-Site Sevoflurane Concentration: A Simulation Study
Anesth. Analg., October 1, 2005; 101(4): 1023 - 1028.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the Canadian Anesthesiologists' Society.