CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Preckel, B.
Right arrow Articles by Schlack, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Preckel, B.
Right arrow Articles by Schlack, W.

Canadian Journal of Anesthesia, Vol 46, 1076-1081, Copyright © 1999 by Canadian Anesthesiologists' Society

ARTICLES

Beneficial effects of sevoflurane and desflurane against myocardial reperfusion injury after cardioplegic arrest

B Preckel, V Thamer and W Schlack
Institut fur Klinische Anaesthesiologie and Physiologisches Institut I, Dusseldorf, Germany.

PURPOSE: To determine whether sevoflurane or desflurane offer additional protective effects against myocardial reperfusion injury after protecting the heart against the ischemic injury by cardioplegic arrest. METHODS: Isolated rat hearts in a Langendorff-preparation (n = 9) were arrested by infusion of HTK cardioplegic solution and subjected to 30 min global ischemia followed by 60 min reperfusion (controls). An additional 18 hearts were subjected to the same protocol, and sevoflurane (n = 9) or desflurane (n = 9) was added to the perfusion medium during the first 30 min of reperfusion in a concentration corresponding to 1.5 MAC in rats. Left ventricular (LV) developed pressure and creatine kinase (CK) release were determined as indices of myocardial performance and cellular injury, respectively. RESULTS: The LV developed pressure recovered to 46+/-7% of baseline in controls. Functional recovery during reperfusion was improved by inhalational anesthetics to 67+/-3% (sevoflurane, P<0.05) and 61+/-5% of baseline (desflurane, P<0.05), respectively. Peak CK release during early reperfusion was reduced from 52+/-11 U x min(-1) x g(-1) in controls to 34+/-7 and 26+/-7 U x min(-1) x g(-1) in sevoflurane and desflurane treated hearts, respectively. The CK release during the first 30 min of reperfusion was reduced from 312+/-41 U x g(-1) in control hearts to 195+/-40 and 206+/-37 U x g(-1) in sevoflurane and desflurane treated hearts. CONCLUSION: After ischemic protection by cardioplegia, sevoflurane and desflurane given during the early reperfusion period offer additional protection against myocardial reperfusion injury.


This article has been cited by other articles:


Home page
 Br J AnaesthHome page
M. Zaugg, M. C. Schaub, and P. Foex
Myocardial injury and its prevention in the perioperative setting
Br. J. Anaesth., July 1, 2004; 93(1): 21 - 33.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
D. Obal, H. Scharbatke, H. Barthel, B. Preckel, J. Mullenheim, and W. Schlack
Cardioprotection against reperfusion injury is maximal with only two minutes of sevoflurane administration in rats: [La cardioprotection contre les lesions de reperfusion est maximale apres deux minutes seulement d'administration de sevoflurane chez des rats]
Can J Anesth, November 1, 2003; 50(9): 940 - 945.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
R. Kato and P. Foex
Myocardial protection by anesthetic agents against ischemia-reperfusion injury: an update for anesthesiologists: [La protection myocardique contre les lesions d'ischemie-reperfusion par des anesthesiques : une mise a jour pour les anesthesiologistes]
Can J Anesth, October 1, 2002; 49(8): 777 - 791.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
D. Ebel, B. Preckel, A. You, J. Mullenheim, W. Schlack, and V. Thamer
Cardioprotection by sevoflurane against reperfusion injury after cardioplegic arrest in the rat is independent of three types of cardioplegia
Br. J. Anaesth., June 1, 2002; 88(6): 828 - 835.
[Abstract] [Full Text] [PDF]

Home page
 Ann. Thorac. Surg.Home page
B. Pouzet, J.-B. Lecharny, M. Dehoux, S. Paquin, M. Kitakaze, J. Mantz, and P. Menasche
Is there a place for preconditioning during cardiac operations in humans?
Ann. Thorac. Surg., March 1, 2002; 73(3): 843 - 848.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
D. Obal, B. Preckel, H. Scharbatke, J. Mullenheim, F. Hoterkes, V. Thamer, and W. Schlack
One MAC of sevoflurane provides protection against reperfusion injury in the rat heart in vivo
Br. J. Anaesth., December 1, 2001; 87(6): 905 - 911.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
J. Mullenheim, A. Molojavyi, B. Preckel, V. Thamer, and W. Schlack
Thiopentone does not block ischemic preconditioning in the isolated rat heart : [Le thiopental n'entrave pas le preconditionnement ischemique dans le coeur de rat isole]
Can J Anesth, September 1, 2001; 48(8): 784 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
B. Preckel, J. Mullenheim, A. Moloschavij, V. Thamer, and W. Schlack
Xenon Administration During Early Reperfusion Reduces Infarct Size After Regional Ischemia in the Rabbit Heart In Vivo
Anesth. Analg., December 1, 2000; 91(6): 1327 - 1332.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the Canadian Anesthesiologists' Society.