CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ikeno, S.
Right arrow Articles by Satoh, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ikeno, S.
Right arrow Articles by Satoh, M.

Canadian Journal of Anesthesia, Vol 46, 148-153, Copyright © 1999 by Canadian Anesthesiologists' Society

ARTICLES

Propofol does not affect the canine cardiac conduction system under autonomic blockade

S Ikeno, S Akazawa, R Shimizu, Y Nakaigawa, R Ishii, S Inoue and M Satoh
Department of Anaesthesiology, Jichi Medical School, Tochigi, Japan. sakazawa@jichi.ac.jp

PURPOSE: To determine the effects of propofol on the cardiac conduction system in dogs with pharmacological autonomic blockade. METHODS: In eight mongrel dogs receiving 6 mg.kg-1.hr-1 propofol and vecuronium under pharmacological autonomic blockade with atropine and propranolol the infusion rates of propofol were increased from 6, (baseline), to 12, 18 and 24 mg.kg-1.hr-1 at 60-min intervals. An electrophysiological study assessed sinus rate, sinus node recovery time, corrected sinus node recovery time, intraatrial conduction time, AV nodal effective refractory period, Wenckebach cycle length and AV conduction times. Electrocardiographical variables and arterial pressures were also measured. All measurements were repeated at 30 min after the beginning of each infusion of propofol. RESULTS: Propofol did not produce direct effects on the electrophysiological or electrocardiographical variables at any infusion rates. Heart rates did not change at higher infusion rates in the presence of decreases in arterial pressures. CONCLUSION: Propofol did not affect the cardiac conduction system in the presence of autonomic blockade. Thus, the direct cardiac effects of propofol do not play a causative role in the genesis of propofol-associated bradyarrhythmias.


This article has been cited by other articles:


Home page
 Canadian J. AnesthesiaHome page
J. E. Burjorjee and B. Milne
Propofol for electrical storm; a case report of cardioversion and suppression of ventricular tachycardia by propofol: [Le propofol et la tempete electrique; l'observation d'un cas de cardioversion et de suppression de la tachycardie ventriculaire par le propofol]
Can J Anesth, November 1, 2002; 49(9): 973 - 977.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1999 by the Canadian Anesthesiologists' Society.