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Canadian Journal of Anesthesia, Vol 46, 564-566, Copyright © 1999 by Canadian Anesthesiologists' Society

ARTICLES

Rhabdomyolysis in association with Duchenne's muscular dystrophy

R Obata, Y Yasumi, A Suzuki, Y Nakajima and S Sato
Department of Anesthesiology and Intensive Care, Hamamatsu University School of Medicine, Japan.

PURPOSE: To present a case of rhabdomyolysis which developed in a child with a known history of Duchenne's muscular dystrophy, following an anesthetic which included sevoflurane. CLINICAL FEATURES: An 11 yr old boy with a known history of Duchenne's muscular dystrophy underwent anesthesia for strabismus repair. The anesthetic consisted of sevoflurane and nitrous oxide without the use of a muscle relaxant. His postoperative course was complicated by a complaint of heel pain and the development of myoglobinuria. He was treated with dantrolene sodium and discharged home after two days, without further complication. CONCLUSION: Sevoflurane anesthesia has not been shown previously to be associated with the development of acute rhabdomyolysis in a child with a history of Duchenne's muscular dystrophy. As with halothane and isoflurane, the continued use of sevoflurane in the presence of Duchenne's muscular dystrophy should be questioned.


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A. Nathan, A. Ganesh, R. I. Godinez, S. C. Nicolson, and W. J. Greeley
Hyperkalemic Cardiac Arrest After Cardiopulmonary Bypass in a Child with Unsuspected Duchenne Muscular Dystrophy
Anesth. Analg., March 1, 2005; 100(3): 672 - 674.
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Copyright © 1999 by the Canadian Anesthesiologists' Society.