| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Canadian Journal of Anesthesia, Vol 46, 641-648, Copyright © 1999 by Canadian Anesthesiologists' Society
ARTICLES |
DM Ansley, J Sun, WA Visser, J Dolman, DV Godin, ME Garnett and AK Qayumi
Department of Anaesthesia, University of British Columbia, Vancouver, Canada. daansley@unixg.ubc.ca
PURPOSE: To compare low vs. high dose propofol and isoflurane on red cell RBC antioxidant capacity in patients during aortocoronary bypass surgery (ACBP). METHODS: Twenty-one patients, for ACBP, were anesthetized with sufentanil 0.5-10 microg x kg(-1) and isoflurane 0-2%; ISO = control; n = 7), or sufentanil 0.3 microg x kg(-1), propofol 1-2.5 mg x kg(-1) bolus then 100 microg x kg(-1) min(-1) before, and 50 microg x kg(-1) x min(-1) during CPB (LO; n = 7), or sufentanil 0.3 microg x kg(-1), propofol 2-2.5 mg x kg(-1) bolus then 200 microg x kg(-1) x min(-1) (HI; n = 7). Venous blood was drawn pre- and post-induction, after 30 min CPB, 5, 10, and 30 min of reperfusion, and 120 min post-CPB to measure red cell antioxidant capacity (malondialdehyde (MDA) production in response to oxidative challenge with t-butyl hydrogen peroxide) and plasma propofol concentration. Pre- induction blood samples were analyzed for antioxidant effects of nitrates on red cells. The tBHP concentration response curves for RBC MDA in ISO, LO and HI were determined. RESULTS: Preoperative nitrate therapy did not effect RBC MDA production. Perioperative RBC MDA production was similar in ISO and LO groups. Sustained intraoperative decrease in RBC MDA was seen with propofol 8.0+/-2.4 - 11.8+/-4.5 microg x ml(-1) in HI (P<0.05-0.0001). MDA production vs. log plasma propofol concentration was linear in HI dose. CONCLUSIONS: During CPB, RBC antioxidant capacity is enhanced and maintained with HI dose propofol. Propofol, at this dose, may prove useful in protecting against cardiopulmonary ischemia-reperfusion injury associated with ACBP.
This article has been cited by other articles:
 |
|
 |
|
  Z. Xia, Z. Huang, and D. M. Ansley Large-Dose Propofol During Cardiopulmonary Bypass Decreases Biochemical Markers of Myocardial Injury in Coronary Surgery Patients: A Comparison with Isoflurane. Anesth. Analg., September 1, 2006; 103(3): 527 - 532. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. M. Rodriguez-Lopez, P. Sanchez-Conde, F. S. Lozano, J. L. Nicolas, F. J. Garcia-Criado, C. Cascajo, and C. Muriel Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery: [Essai en laboratoire : les effets du propofol sur la reaction inflammatoire generalisee pendant une operation de l'aorte]. Can J Anesth, July 1, 2006; 53(7): 701 - 710. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Luo and Z. Xia A small dose of hydrogen peroxide enhances tumor necrosis factor-alpha toxicity in inducing human vascular endothelial cell apoptosis: reversal with propofol. Anesth. Analg., July 1, 2006; 103(1): 110 - 116. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. Luo, Z. Xia, D. M. Ansley, J. Ouyang, D. J. Granville, Y. Li, Z.-Y. Xia, Q.-S. Zhou, and X.-Y. Liu Propofol Dose-Dependently Reduces Tumor Necrosis Factor-{alpha}-Induced Human Umbilical Vein Endothelial Cell Apoptosis: Effects on Bcl-2 and Bax Expression and Nitric Oxide Generation Anesth. Analg., June 1, 2005; 100(6): 1653 - 1659. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. M. Ansley, Z. Huang, and Z. Xia MYOCARDIAL PRESERVATION WITH PROPOFOL IS DOSE-DEPENDENT Can J Anesth, June 1, 2005; 52(suppl_1): A37 - A37. [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Xia, D. V. Godin, and D. M. Ansley Propofol enhances ischemic tolerance of middle-aged rat hearts: effects on 15-F2t-isoprostane formation and tissue antioxidant capacity Cardiovasc Res, July 1, 2003; 59(1): 113 - 121. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. Thompson, G. Wisenberg, J. Sykes, and R. T. Thompson Similar long-term cardiovascular effects of propofol or isoflurane anesthesia during ischemia/ reperfusion in dogs: [Effets cardiovasculaires prolonges similaires de l'anesthesie au propofol ou a l'isoflurane pendant l'ischemie/reperfusion chez les chiens] Can J Anesth, November 1, 2002; 49(9): 978 - 985. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. M. Sayin, O. Ozatamer, R. Tasoz, K. Kilinc, and N. Unal Propofol attenuates myocardial lipid peroxidation during coronary artery bypass grafting surgery{dagger} Br. J. Anaesth., August 1, 2002; 89(2): 242 - 246. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. D. Runzer, D. M. Ansley, D. V. Godin, and G. K. Chambers Tissue Antioxidant Capacity During Anesthesia: Propofol Enhances In Vivo Red Cell and Tissue Antioxidant Capacity in a Rat Model Anesth. Analg., January 1, 2002; 94(1): 89 - 93. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Klemm, C. Voigt, M. Friedrich, R. Funfstuck, H. Sperschneider, E.-G. Jager, and G. Stein Determination of erythrocyte antioxidant capacity in haemodialysis patients using electron paramagnetic resonance Nephrol. Dial. Transplant., November 1, 2001; 16(11): 2166 - 2171. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Yamaguchi, S. Hamaguchi, M. Mishio, Y. Okuda, and T. Kitajima Propofol prevents lipid peroxidation following transient forebrain ischemia in gerbils Can J Anesth, October 1, 2000; 47(10): 1025 - 1030. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
