This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Okano, N. Articles by Goto, F. Search for Related Content PubMed PubMed Citation Articles by Okano, N. Articles by Goto, F. Related Collections Cardiothoracic Anesthesia, Respiration and Airway

Cerebral oxygenation is better during mild hypothermic than normothermic cardiopulmonary bypass

Nobuhiro Okano, MD^*, Ryo-ichi Owada, MD^*, Nao Fujita, MD^*, Yuji Kadoi, MD, Shigeru Saito, MD and Fumio Goto, MD

^* From the Department of Anesthesiology,
Saitama Cardiovascular and Pulmonary Center, Saitama, Japan and the Department of Anesthesiology and Reanimatology Gunma University, School of Medicine, Gunma, Japan.

Dr. Yuji Kadoi, Department of Anesthesiology and Reanimatology, Gunma University, School of Medicine, 3-39-22 Showa-machi, Maebashi, Gunma 371-8511, Japan. Phone: 81-272-20-7111; Fax: 81-272-20-8473; E-mail: kadoi{at}akagi.sb.gunma-u.ac.jp

Purpose: Normothermic cardiopulmonary bypass (CPB) has been recently used in cardiac surgery. However, there is a controversy whether there is a difference in incidence of neurological disorder after coronary artery bypass graft (CABG) surgery between normothermic CPB and mild hypothermic CPB. In this study, we assessed the effects of normothermia and mild hypothermia (32°C) during CPB on jugular oxygen saturation (SjvO₂).

Methods: Twenty patients scheduled for elective CABG surgery were divided into two groups. Group 1 (n=10) underwent normothermic (>35°C) CPB, and Group 2 (n=10) underwent mild hypothermic (32°C) CPB. Alpha-stat blood gas regulation was applied. After inducing anesthesia, a 4.0 French fibre optic oximetry oxygen saturation catheter was inserted into the right jugular bulb to monitor SjvO₂ continuously throughout anesthesia and surgery.

Results: The SjvO₂ in the normothermic group was decreased at 20 (41.5 ± 2.4%) and 40 min (43.8 ± 2.8%) after the onset of CPB compared with control (53.9 ± 5.4%, P < 0.05). However, there was no change in SjvO₂ in the mild hypothermic group during the study. No changes in jugular venous-arterial differences of lactate or creatine phosphokinase isoenzyme BB were observed in two groups during the study.

Conclusions: Cerebral oxygenation, as assessed by SjvO_2, was increased during mild hypothermic CPB than during normothermic CPB.

This article has been cited by other articles:

				R. A. Baker, L. J. Hallsworth, and J. L. Knight Stroke After Coronary Artery Bypass Grafting Ann. Thorac. Surg., November 1, 2005; 80(5): 1746 - 1750. [Abstract] [Full Text] [PDF]

				H. P. Grocott, T. M. Hemmerling, and J. D. Fortier False Increase BIS Values with Forced-Air Head Warming * Response Anesth. Analg., April 1, 2003; 96(4): 1230 - 1230. [Full Text] [PDF]