| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
From the Department of Anaesthesia, St. Michael's Hospital and the Department of Pharmacology, University of Toronto.
Address correspondence to: Dr. Susan Belo, Department of Anaesthesia, St. Michael's Hospital, 30 Bond Street, Toronto, Ontario, M5B 1W8 Canada. Phone: 416-864-5071; Fax: 416-864-6014; E-mail: belos{at}smh.toronto.on.ca
Purpose: To determine the efficacy of ondansetron and droperidol, alone and in combination, administered for prophylaxis of postoperative nausea and vomiting (PONV) in women undergoing general anesthesia for out-patient gynecological laparoscopy.
Methods: Following Institutional Ethics Board approval and patient consent, 160 female out- patients scheduled for laparoscopy were randomly allotted in a double-blind fashion to receive: i) saline (placebo), ii) 4 mg ondansetron, iii) 1.25 mg droperidol, or iv) 4 mg ondansetron and 1.25 mg droperidol combination intravenously on induction. Following a standardized general anesthesia, patients were interviewed and assessed for PONV at various times.
Results: During the first 24 hr after surgery, the incidence of PONV in the placebo group was 71%. This was reduced to 61% with droperidol alone (P = 0.334), to 46% with ondansetron alone (P = 0.027), and to 23% with the combination group (P < 0.001). A statistically significant difference was observed between combination and droperidol (P < 0.001) and between combination and ondansetron (P = 0.036). There were fewer requests for rescue medication from the combination group (7.7%) than from the ondansetron and placebo groups.
Conclusion: The results of this study suggest that the combination of 4 mg ondansetron and 1.25 mg droperidol is more efficacious as a prophylactic anti-emetic than either agent alone during the 24 hr post-surgery. This additive effect may be due to the different mechanisms of action of ondansetron and droperidol.
This article has been cited by other articles:
 |
|
 |
|
  M. T. V. Chan, K. C. Choi, T. Gin, P. T. Chui, T. G. Short, P. M. Yuen, A. H. Y. Poon, C. C. Apfel, and T. J. Gan The Additive Interactions Between Ondansetron and Droperidol for Preventing Postoperative Nausea and Vomiting Anesth. Analg., November 1, 2006; 103(5): 1155 - 1162. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Goldfaden and J. D. Birkmeyer Evidence-Based Practice in Laparoscopic Surgery: Perioperative Care Surgical Innovation, March 1, 2005; 12(1): 51 - 61. [Abstract] [PDF]
|
|
|
|
 |
|
 A. S. Habib, H. E. El-Moalem, and T. J. Gan The efficacy of the 5-HT3 receptor antagonists combined with droperidol for PONV prophylaxis is similar to their combination with dexamethasone. A meta-analysis of randomized controlled trials: [L'efficacite de la combinaison des antagonistes des recepteurs 5-HT3 et du droperidol ou de la dexame- thasone est similaire pour prevenir les NVPO. Une meta-analyse d'essais randomises et controles] Can J Anesth, April 1, 2004; 51(4): 311 - 319. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. S. Beattie Strategies to reduce postoperative nausea and vomiting: does metoclopramide have a role?/Reduction des nausees et vomissements postoperatoires : le metoclopramide y joue-t-il un role ? Can J Anesth, December 1, 2002; 49(10): 1009 - 1015. [Full Text] [PDF]
|
|
|
|
|
|
M. Boehler, G. Mitterschiffthaler, and A. Schlager Korean Hand Acupressure Reduces Postoperative Nausea and Vomiting After Gynecological Laparoscopic Surgery Anesth. Analg., April 1, 2002; 94(4): 872 - 875. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
