CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Résumé de cet Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ichinohe, T.
Right arrow Articles by Kaneko, Y.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ichinohe, T.
Right arrow Articles by Kaneko, Y.
Related Collections
Right arrow General Anesthesia
Canadian Journal of Anesthesia 47:699-704 (2000)
© Canadian Anesthesiologists' Society, 2000
Laboratory Investigations

Interaction of nitrous oxide and propofol to reduce hypertensive response to stimulation

Tatsuya Ichinohe, DDS PhD, Hidetaka Aida, DDS PhD and Yuzuru Kaneko, DDS PhD

From the Department of Dental Anesthesiology, Tokyo Dental College, 1-2-2, Masago, Mihama-ku, Chiba, 261-0011 Japan.

Address correspondence to: Dr. Tatsuya Ichinohe. Phone: 81-43-270-3969; Fax: 81-43-270-3971; E-mail: ichinohe{at}tdc.ac.jp

Purpose: To evaluate the interaction between nitrous oxide and propofol for the suppression of hypertension following electrical stimulation of the mental nerve in the rabbit.

Methods: Male Japan White rabbits were tracheostomized, cannulated and mechanically ventilated under isoflurane anesthesia. Square wave pulses (5 V, 0.5 msec, 50 Hz for 5 sec) were delivered to the left mental nerve. Animals received nitrous oxide 20, 40, 60 and 80% (Group 1); propofol 200, 400, 600 and 800 µg•kg–1•min–1 (Group 2); or combinations of nitrous oxide and propofol at 10 + 100, 20 + 200, 30 + 300 and 40 % + 400 µg•kg–1•min–1 (Group 3). Systolic blood pressure was recorded from immediately before to maximal increase following nerve stimulation. Probit analysis was used to obtain ED50 values for 50% suppression of blood pressure elevation. Isobolographic analysis was used to evaluate the interaction between nitrous oxide and propofol.

Results: ED50 values are 52.9% for nitrous oxide (Group 1), 464.1 µg•kg–1•min–1 for propofol (Group 2), 21.7 % + 217.1 µg•kg–1•min–1 for nitrous oxide and propofol combination (Group 3) and 24. 7 % + 247.1 µg•kg–1•min–1 for the theoretically additive combination of nitrous oxide and propofol, respectively.

Conclusion: The interaction between nitrous oxide and propofol for the suppression of blood pressure elevation following electrical stimulation of the mental nerve is additive.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2000 by the Canadian Anesthesiologists' Society.