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Right arrow General Anesthesia
Canadian Journal of Anesthesia 47:786-791 (2000)
© Canadian Anesthesiologists' Society, 2000
Reports of Investigation

Acute changes in bladder volume produce minimal cardio-respiratory responses in lightly anesthetised humans

Teruhiko Ishikawa , MD, Jiro Sato, MD and Takashi Nishino, MD

From the Department of Anesthesiology, Chiba University School of Medicine, Inohana 1-8-1, Chiba 260-8670, Japan.

Address correspondence to: Teruhiko Ishikawa md. Phone: +81-43-226-2155; Fax: +81-43-226-2156; E-mail: iteru{at}anesth01.m.chiba-u.ac.jp

Purpose: To examine whether changes in bladder volume elicit reflex cardiovascular and respiratory responses in humans under general anesthesia with sevoflurane and nitrous oxide.

Methods: Fourteen patients free of autonomic disorders were anesthetized with sevoflurane 0.5% and nitrous oxide 60% in oxygen that were approximately equivalent to 0.9 MAC. Warmed saline (6 ml•kg–1, 37°C) was instilled into the pre-emptied urinary bladder, and then the bladder was kept distended for five minutes. Following the distension, the instilled saline was drained to the pre-instilled volume of the bladder. Arterial blood pressure, respiratory flow, and intra-vesicle pressure were continuously measured, and mean arterial pressure, pulse rate, respiratory rate, tidal volume, and minute ventilation were estimated offline from these signals.

Results: Bladder emptying produced small decreases in mean blood pressure (from 83.4 ± 4.3 to 80.0 ± 4.4 mmHg, mean ± SE, P =0.017) and pulse rate (from 72.2 ± 2.9 to 69.4 ± 2.7 bpm, mean ± SEM, P =0.004). Only minimal respiratory reflexes were invoked by the bladder volume changes.

Conclusion: In lightly anesthetized humans, the acute changes in bladder volume produce only mild cardiovascular and respiratory responses.






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Copyright © 2000 by the Canadian Anesthesiologists' Society.