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Canadian Journal of Anesthesia 47:819-822 (2000)
© Canadian Anesthesiologists' Society, 2000
Brief Report

Effect of xenon on diaphragmatic contractility in dogs

Takuo Hoshi, MD, Yoshitaka Fujii, MD, Shinji Takahashi, MD and Hidenori Toyooka, MD

From the Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.

Address correspondence to: Dr.Y. Fujii, Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305, Japan. Phone: 0298-53-3763; Fax: 0298-53-3765; E-mail: yfujii{at}igaku.md.tsukuba.ac.jp

Purpose: This study was undertaken to examine the effect of xenon on diaphragmatic contractility in pentobarbitone-anesthetized, mechanically ventilated dogs.

Methods: Twenty-one dogs were randomly allocated to three groups (n=7 of each): Group I received oxygen 100% ; Group II received xenon 30% in oxygen; Group III received xenon 60% in oxygen. Diaphragmatic contractility was assessed by measuring transdiaphragmatic pressure (Pdi) generated during supramaximal stimulation of phrenic nerves at the neck at low-frequency (20-Hz) and high-frequency (100-Hz) stimulation, after maintaining 60 min of stable condition.

Results: With inhalation of xenon at two different concentration (30% and 60%), no changes were observed in Pdi at either concentration. There was no difference in Pdi among the three groups.

Conclusion: Increasing the concentration of xenon to 60% has no effect on diaphragmatic contractility in dogs. This suggests that xenon may be used safely as an anesthetic with respect to respiratory muscle function.






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