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In rabbits, landiolol, a new ultra-short-acting ß-blocker, exerts a more potent negative chronotropic effect and less effect on blood pressure than esmolol

[Le landiolol, un nouveau ß-bloquant à action très brève, a un effet chronotropic négatif plus puissant et agit moins sur la tension artérielle que l'esmolol chez le lapin]

Junichi Sasao, MD^*, Stephen D. Tarver, MD^*, James D. Kindscher, MD^*, Chikuni Taneyama, MD, Kirk T. Benson, MD^* and Hiroshi Goto, MD^*

^* From the Department of Anesthesiology, University of Kansas Medical Center, Kansas City, Kansas, USA; and
the Clinic of Taneyama, Shiojiri-shi, Japan.

Dr. Hiroshi Goto, Department of Anesthesiology, University of Kansas Medical Center, 3901 Rainbow Blvd., Kansas City, Kansas USA 66160-7415. Phone: 913-588-6670; Fax: 913-588-3365; E-mail: hgoto{at}kumc.edu

Purpose: To compare the cardiovascular and sympathetic effects of a new ultra-short-acting, highly cardioselective ß- blocker, landiolol, with esmolol, using an in vivo rabbit model.

Methods: Different bolus doses of landiolol (0.3, 1.0, 3.0 and 10.0 mg•kg^–1) or esmolol (0.5, 1.5 and 5.0 mg•kg^–1) were given intravenously, and the effects on heart rate (HR) mean arterial pressure (MAP) and renal sympathetic nerve activity (RSNA) were compared.

Results: Both landiolol and esmolol produced a dose-dependent decrease in HR. The maximum percent reductions of HR were similar with landiolol 3 mg•kg^–1 and esmolol 5 mg•kg^–1 (-14.0 ± 0.9% and -13.9 ± 1.4%, mean ± SE, respectively). HR decreased more rapidly with landiolol than with esmolol. Esmolol produced a dose-dependent decrease in MAP that was not observed with landiolol. The percent maximum reduction of MAP was -38.2 ± 3.2% with esmolol 5 mg•kg^–1. RSNA increased in a dose-dependent fashion with esmolol, but no changes were noted with landiolol.

Conclusion: These results suggest that, in rabbits, landiolol has slightly more potent negative chronotropic action than esmolol with significantly less effects on blood pressure.

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