This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by O'Hanlon, D. M. Articles by Given, H. F. Search for Related Content PubMed PubMed Citation Articles by O'Hanlon, D. M. Articles by Given, H. F.

Timing of pre-emptive tenoxicam is important for postoperative analgesia

^* From the National Breast Cancer Research Institute and Department of Surgery and Anesthesiology, University College Hospital, Galway, Ireland.

Address correspondence to:Dr. H. Fred Given, University College Hospital, Galway, Ireland. Phone: 353-1-91-524222; Fax: 353-1-91-750509.

Purpose: In this prospective randomized study, a comparison was made between the efficacy of 20 mg tenoxicam, administered either, 30 min preoperatively or at induction of anesthesia, for the relief of postoperative pain in patients undergoing ambulatory breast biopsy.

Methods. Seventy-three patients were recruited and all received a standard anesthetic consisting of induction with 2 mg•kg^–1 propofol followed by 5 µg•kg^–1 alfentanyl. No premedication was administered and at the end of the procedure the wounds were infiltrated with 10 ml of bupivacaine (0.5 %). Patients were randomized to receive 20 mg tenoxicam intraveneously either 30 min before surgery or at induction of anesthesia.

Results: Demographic criteria were similar in both groups. There were differences in pain scores at 30, 60, 120 and 240 min postoperatively (VAS at 30 min 3.2 ± 1.2 vs 5.5 ± 1.8; P < 0.001: VAS at 60 min 1.8 ± 1.2 vs 3.7 ± 1.9; P < 0.001: VAS at 120 min 0.9 ± 0.9 vs 1.7 ± 1.0; P = 0. 003: VAS at 240 min 0.5 ± 0.5 vs 1.1 ± 0.8; P < 0.001: Expressed as mean ± SD). There was a difference in the number of patients requiring additional analgesia, in the first four hours postoperatively (12 (33%) vs 27 (73%); P = 0.001) and a difference in the time to additional analgesia in these patients (87.5 ± 32.5 vs 55.0 ± 26.8 min; P = 0.002).

Conclusion: Early administration of pre-emptive tenoxicam 30 min before induction of anesthesia improves postoperative analgesia in patients undergoing ambulatory breast biopsy.

This article has been cited by other articles:

				Y. U. Adachi, H. Sano, M. Doi, and S. Sato Preemptive Analgesia by Nonsteroidal Antiinflammatory Drugs Anesth. Analg., November 1, 2006; 103(5): 1331 - 1332. [Full Text] [PDF]

				H.-F Gramke, J. J. J. Petry, M. E. Durieux, J.-P Mustaki, M. Vercauteren, G. Verheecke, and M. A. E. Marcus Sublingual piroxicam for postoperative analgesia: preoperative versus postoperative administration: a randomized, double-blind study. Anesth. Analg., March 1, 2006; 102(3): 755 - 758. [Abstract] [Full Text] [PDF]

				C. K.-S. Ong, P. Lirk, R. A. Seymour, and B. J. Jenkins The Efficacy of Preemptive Analgesia for Acute Postoperative Pain Management: A Meta-Analysis Anesth. Analg., March 1, 2005; 100(3): 757 - 773. [Abstract] [Full Text] [PDF]

				J. B. Dahl and S. Moiniche Pre-emptive analgesia Br. Med. Bull., December 13, 2004; 71(1): 13 - 27. [Abstract] [Full Text] [PDF]

				C. R. McCrory and S. G. E. Lindahl Cyclooxygenase Inhibition for Postoperative Analgesia Anesth. Analg., July 1, 2002; 95(1): 169 - 176. [Full Text] [PDF]

				S. S. Reuben, S. Bhopatkar, H. Maciolek, W. Joshi, and J. Sklar The Preemptive Analgesic Effect of Rofecoxib After Ambulatory Arthroscopic Knee Surgery Anesth. Analg., January 1, 2002; 94(1): 55 - 59. [Abstract] [Full Text] [PDF]

				J. Katz Pre-emptive analgesia: importance of timing/L'analgesie preventive : choisir le bon moment Can J Anesth, February 1, 2001; 48(2): 105 - 114. [Full Text] [PDF]