This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by McGinley, J. Articles by Cunningham, A.J. Search for Related Content PubMed PubMed Citation Articles by McGinley, J. Articles by Cunningham, A.J.

Dopexamine hydrochloride does not modify hemodynamic response or tissue oxygenation or gut permeability during abdominal aortic surgery

J. McGinley, FFARCSI^*, L. Lynch, FRCA, K. Hubbard, SRN^*, D. McCoy, FFARCSI and A.J. Cunningham , MD FRCPC^*

^* From the Departments of Anaesthesia, Professorial Unit, Beaumont Hospital, Dublin, Ireland and
St. James's Hospital, Leeds, UK.

Address correspondence to: Professor A.J. Cunningham, Department of Anaesthesia, Professorial Unit, Beaumont Hospital, Dublin 9, Ireland. Phone: 353-1-8376843; Fax: 353-1-837 0091; E-mail: anthonyc{at}rcsi.ie

Purpose: To assess the effects of intraoperative infusion of dopexamine (a DA-1 and B2 adrenoreceptor agonist) on hemodynamic function, tissue oxygen delivery and consumption, splanchnic perfusion and gut permeability following aortic cross- clamp and release.

Methods: In a randomised double blind controlled trial 24 patients scheduled for elective infrarenal abdominal aortic aneurysm repair were studied in two centres and were assigned to one of two treatment groups. Group I received a dopexamine infusion starting at 0.5 µg•kg^–1•min^–1 increased to 2 µg•kg^–1•min^–1 maintaining a stable heart rate; Group II received a placebo infusion titrated in the same volumes following induction of anesthesia. Measured and derived hemodynamic data, tissue oxygen delivery and extraction and gut permeability were recorded at set time points throughout the procedure.

Results: Dopexamine infusion (0.5 -2 µg•kg^–1•min^–1) was associated with enhanced hemodynamic function (MAP 65 ± 5.5 vs 92 ± 5.7 mm Hg, P =<0.05) only during the period of aortic cross clamping. However, during the most part of infrarenal abdominal aortic surgery, dopexamine did not reduce systemic vascular resistance index, mean arterial pressure nor oxygen extraction compared with the control group. The lactulose/ rhamnose permeation ratio was elevated above normal in both groups (0.22 and 0.29 in groups I and II respectively).

Conclusions: Dopexamine infusion (0.5 -2 µg•kg^–1•min^–1) did not enhance hemodynamic function and tissue oxygenation values during elective infrarenal abdominal aortic aneurysm repair.

This article has been cited by other articles:

				M. C. Renton and C. P. Snowden Dopexamine and its role in the protection of hepatosplanchnic and renal perfusion in high-risk surgical and critically ill patients Br. J. Anaesth., April 1, 2005; 94(4): 459 - 467. [Abstract] [Full Text] [PDF]