This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Andersson, I. Articles by Bengtsson, A. Search for Related Content PubMed PubMed Citation Articles by Andersson, I. Articles by Bengtsson, A.

Complement split products and pro-inflammatory cytokines in salvaged blood after hip and knee arthroplasty

From the Department of Anesthesiology & Intensive Care, East Hospital/Sahlgrenska University Hospital, Gothenburg, Sweden.

Address correspondence to: Dr. Iréne Andersson, Department of Anesthesiology & Intensive Care, East Hospital, Sahlgrenska University Hospital, S-416 85 Gothenburg, Sweden. Phone: 46-31-3434000; Fax: 46-31-3434490; E-mail: irene_maria.andersson{at}sahlgrenska.se

Purpose: To determine whether salvaged autologous blood collected postoperatively contains complement split products (SC5b-9), and pro-inflammatory cytokines (IL-6 and IL-8) and whether there are any differences between blood collected during hip or knee surgery.

Methods: Fifty-eight consecutive patients undergoing hip or knee replacement surgery were studied. Thirty-eight had postoperative bleeding large enough to require infusion of salvaged blood. The salvaged blood was filtered during collection through a 200 µm filter and before infusion a 40 µm filter was used. Samples for complement and cytokine determinations were drawn from the circulation and from the collected blood.

Results: High concentrations of SC5b-9, IL-6, and IL-8 were found in salvaged blood. The concentrations were higher than in the circulation (P < 0.05). The circulating concentrations of IL-6 and IL-8 were increased 60 min and 12-18 hr after transfusion. There were no differences regarding SC5b-9, IL-6, and IL-8 in the blood collected after hip or knee surgery.

Conclusion: Blood collected from a surgical wound contains large concentrations of inflammatory mediators. There were no differences between blood collected during hip or knee surgery.

This article has been cited by other articles:

				R. S. Weber, N. Jabbour, and R. C. G. Martin II Anemia and Transfusions in Patients Undergoing Surgery for Cancer Ann. Surg. Oncol., January 1, 2008; 15(1): 34 - 45. [Abstract] [Full Text] [PDF]

				N Nitescu, A Bengtsson, and J P Bengtson Blood salvage with a continuous autotransfusion system compared with a haemofiltration system Perfusion, September 1, 2002; 17(5): 357 - 362. [Abstract] [PDF]