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Canadian Journal of Anesthesia 48:459-461 (2001)
© Canadian Anesthesiologists' Society, 2001
General Anesthesia

Hypnotic and cardiovascular effects of proprietary and generic propofol formulations do not differ

Argyro Fassoulaki, MD PhD DEAA, Andia Paraskeva, MD, Konstantinos Papilas, MD DEAA and Konstantinos Patris, MD

From the Department of Anesthesia, St Savas Hospital, Athens, Greece.

Address correspondence to: Dr. A. Fassoulaki, 57-59 Raftopoulou Street, 11744 Athens, Greece. Phone: 301- 9024530; Fax: 301-9024530; E-mail: afassou1{at}otenet.gr

Purpose: The aim of the study was to compare the potency of two different propofol formulations: proprietary and generic propofol using the bispectral index (BIS) monitoring.

Methods: Forty female patients undergoing breast surgery received propofol 3 mg•kg–1 followed by propofol infusion adjusted to maintain a 40% BIS value, supplemented by 50% nitrous oxide. Proprietary or generic propofol was administered in a randomized double-blind manner.

Results: The propofol mg/BIS% ratio obtained after the bolus dose, the cumulative infused propofol mg/BIS% ratio at the end of each five-minute interval and the total dose of propofol administered as bolus + infusion were similar between the two groups. The two groups did not differ with regard to systolic and diastolic blood pressure, heart rate, end-tidal carbon dioxide and arterial oxygen saturation.

Conclusion: The two propofol formulations are equipotent when hypnotic effect is assessed by BIS monitoring.




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