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Canadian Journal of Anesthesia 48:570-574 (2001)
© Canadian Anesthesiologists' Society, 2001
Obstetrical and Pediatric Anesthesia

Either sufentanil or fentanyl, in addition to intrathecal bupivacaine, provide satisfactory early labour analgesia

[Le sufentanil ou le fentanyl, ajouté à l'administration intrathécale de bupivacaïne, fournissent une analgésie satisfaisante au début du travail]

Christine Jih-Ching Cheng, FRCA, Alex Tiong-Heng Sia, MB BS MMED, Evangeline Hua-Ling Lim, MB BS, Genevieve Phek-Yee Loke, MB BS and Hsiao Ming Tan, MB BS MMED

From the Department of Anaesthesia, KK Women & Children's Hospital, Singapore.

Address correspondence to: Dr. Alex Tiong-Heng Sia, Department of Anaesthesia, KK Women's and Children's Hospital, 100 Bukit Timah Road, Singapore 229 899. E-mail: athsia{at}kkh.com.sg

Purpose: The study was aimed primarily at comparing the duration of analgesia produced by intrathecal fentanyl 25 µg with sufentanil 5 µg when added to bupivacaine 1.25 mg as the initial component of the combined spinal epidural (CSE) technique in early labour.

Methods: Forty healthy parturients were randomly assigned into two groups to receive either intrathecal sufentanil 5 µg plus bupivacaine 1.25 mg (Group S) or intrathecal fentanyl 25 µg plus bupivacaine 1.25 mg (Group F). Apart from the duration of analgesia, pain scores and side effects were also evaluated.

Results: There was no significant difference in the duration of analgesia (mean 109 ± SD 49 min in Group F vs 118 ± 54 min in Group S, P=0.9). Group F had a more rapid onset of analgesia (P <0.05) and a higher cephalad block (median T4 vs T7, P <0.05) in the first 30 min after the block. No difference in the side effects was detected.

Conclusion: Fentanyl 25 µg is a good alternative to sufentanil 5 µg when added to bupivacaine 1.25 mg for early labour analgesia.




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