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Epi and endomyocardial pH allows the detection of acute right ventricular ischemia in pigs: a new evaluation method

[La connaissance des pH épimyocardique et endomyocardique permet la détection d'ischémie aiguë du ventricule droit chez des porcs : une nouvelle méthode d'évaluation]

Yoanna K. Skrobik, MD FRCPC^* and Janos G. Filep, MD

^* From the Critical Care Division, Maisonneuve Rosemont Hospital, and
the Department of Medicine, Guy-Bernier Research Center, Université de Montréal, Montréal, Québec, Canada.

Address correspondence to: Dr. Yoanna K. Skrobik, Critical Care Division, Maisonneuve Rosemont Hospital, 5415 Boul. de l'Assomption, Montréal, Québec H1T 2M4, Canada. Phone: 514-252-3400; Fax: 514-939-8891; E-mail: skrobiky{at}total.net

Background: Techniques which identify acute right ventricular (RV) ischemia may help elucidate the pathophysiology of RV dysfunction. This study's goal was to validate an acute RV ischemia or infarction detection technique. Could RV endomyocardial and epimyocardial (interstitial) pH electrodes detect RV pH changes in an animal model of RV infarction produced by right coronary artery ligation?

Methods: In ten adult anesthetized pigs, RV interstitial (pHepi) and transmural endomyocardial pH (pHendo) were measured before and serially after right coronary occlusion.

Results: pHendo and pHepi fell significantly following coronary occlusion. The absolute and relative rates of change were greater for pHendo (mean pH decreased from 7.36 to 7.04) compared to pHepi ( mean pH of 7.28 vs 7.08; P <0.002). pH was unchanged in control experiments where the electrode was placed in the right atrial or ventricular chamber, and in sham-operated animals. These data suggest that coronary ligation induced RV ischemia produces RV myocardial pH changes, which can be recorded from an electrode placed against the RV wall via a central vein, or in the interstitium.

Conclusion: This newly described technique may be helpful in developing more discriminating tools to identify acute RV ischemia.

This article has been cited by other articles:

				M. Carrier Endomyocardial pH and right ventricular ischemia: not just another tool?/L'etude du pH endomyocardique et de l'ischemie ventriculaire droite, un outil comme les autres? Can J Anesth, January 1, 2002; 49(1): 5 - 7. [Full Text] [PDF]