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The Panomat^® P-10 micro-volumetric infusion pump is suitable for continuous drug administration at minimal flow rates

[La pompe à perfusion microvolumétrique Panomat^® P-10 convient à l’administration continue de médicament à débit minimal]

Thomas A. Neff, MD^*,, Claudia Fellmann, MD^*, Rudolf M. Fuechslin, MD, Andreas C. Gerber, AC^* and Markus Weiss, MD^*

^* From the Department of Anaesthesia, University Children’s Hospital Zurich, Switzerland
the Department of Anaesthesia, University Hospital Zurich, Switzerland
and the Research Department, BioMIP, Schloss Birlinghoven, St. Augustin, Germany

Address correspondence to: Dr. Markus Weiss, Department of Anaesthesia, University Children’s Hospital, Steinwiesstrasse 75, CH-8032 Zurich, Switzerland. Phone: +41 1 266 77 53; Fax:+41 1 266 71 68; E-mail: markus.weiss{at}kispi.unizh.ch

Purpose: To evaluate the performance of the Panomat® P-10 micro-volumetric infusion pump for its use in drug administration at minimal flow rates (µL•hr^-1; e.g., intrathecal application).

Methods: Fluid delivery at steady state conditions, and after vertical displacement of the syringe pump by -50 cm was determined gravimetrically. The Panomat® P-10 infusion pump was evaluated at 4, 10, 20, 50 and 100 µL•hr^-1, and compared to a conventional syringe pump assembly at 100, 200, 500 and 1000 µL•hr^-1. Measurements were repeated twice with two different devices of each syringe pump system, and with two syringes. Data are reported as mean ± SD.

Results: Steady state fluid delivery of the Panomat® P-10 infusion pump revealed less than 5% deviation to set flow rate at 10, 20, 50 and 100 µL•hr^-1, and 12% deviation at 4 µL•hr^-1. Mean zero-drug delivery time (ZDDT) after lowering the pump by 50 cm at 4 µL•hr^-1 flow rate was 38.4 ± 7.3 min. At 100 µL•hr^-1 and with original infusion line ZDDT was almost 20 times shorter when compared to the conventional syringe pump assembly (1.5 ± 0.5 min vs 28.5 ± 5.0 min).

Conclusion: The tested Panomat® P-10 micro-volumetric pump shows an acceptable flow accuracy as well as a low susceptibility to vertical displacement, and is therefore suitable for continuous drug administration at minimal flow rates. The technology used in this pump carries potential implications for a new generation of syringe pumps.

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