This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Weiss, M. Articles by Baenziger, O. Search for Related Content PubMed PubMed Citation Articles by Weiss, M. Articles by Baenziger, O.

Transcutaneously measured near-infrared spectroscopic liver tissue oxygenation does not correlate with hepatic venous oxygenation in children

[La mesure transcutanée de l’oxygénation du tissu hépatique par spectroscopie proche infrarouge ne correspond pas à l’oxygénation hépatique veineuse chez les enfants]

Markus Weiss, MD^*,, Gabriele Schulz, MD^*,, Margrit Fasnacht, MD, Christian Balmer, MD, Joachim E. Fischer, MD MS^*, Andreas C. Gerber, MD, Hans-Ulrich Bucher, MD and Oskar Baenziger, MD^*

^* From the Departments of Intensive Care and Neonatology,
Anaesthesia, and
Cardiology, University Children’s Hospital and
the Clinic Of Neonatology University Hospital, Zurich, Switzerland.

Dr. Markus Weiss, Department of Anaesthesia and Department of Intensive Care and Neonatology, University Children’s Hospital, Steinwiesstrasse 75, 8032 Zurich, Switzerland. Phone: +41 1 266 71 11; Fax:+41 1 266 79 94; E-mail: markus.weiss{at}kispi.unizh.ch

Purpose: To compare transcutaneous near-infrared spectroscopic (NIRS) measured liver tissue oxygenation with hepatic vein oxygen saturation (SvhO₂) in children undergoing cardiac catheterization.

Methods: A NIRS optode (containing an emitter and a receiver of near-infrared light) was placed directly below the right costal arch above the palpable liver in 40 children aged 0.02 to 7.28 yr (median: 1.8 yr). Spatially resolved spectroscopic measured tissue oxygenation index (TOI) was recorded using the NIRO-300^TM. Paired blood samples from the hepatic vein were taken under radiological control for determination of SvhO₂ in a co-oxymeter. TOI values were compared with hepatic vein oxygenation, with simultaneously obtained arterial oxygen saturation (SaO₂), inferior vena cava SO₂ and hemoglobin concentration using simple linear and multi-regression analysis.

Results: TOI values ranged from 35% to 73% (58.6 ± 8.4%); SvhO₂ from 32% to 80% (58.4 ± 14.4%), and arterial SO₂ from 54% to 100% (90.0 ± 11.4%). TOI and hepatic vein oxygen saturation failed to correlate (r = 0.052/P = 0.752). A regression model containing arterial saturation (R² = 0.177) and the ratio of pulmonary to systemic resistance (R² = 0.095) explained 27.3% of the observed variance in TOI. In this model, hepatic vein oxygen saturation was no longer significant; explaining only 3.4% of the variance. No other variable retained a significant association.

Conclusion: Transcutaneously measured NIRS tissue oxygenation with an optode placed over the palpable liver does not correlate with SvhO₂. The value is dominated by non-hepatic variables such as arterial saturation and vascular resistances.

This article has been cited by other articles:

				J Li, G S Van Arsdell, G Zhang, S Cai, T Humpl, C A Caldarone, H Holtby, and A N Redington Assessment of the relationship between cerebral and splanchnic oxygen saturations measured by near-infrared spectroscopy and direct measurements of systemic haemodynamic variables and oxygen transport after the Norwood procedure Heart, November 1, 2006; 92(11): 1678 - 1685. [Abstract] [Full Text] [PDF]