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Canadian Journal of Anesthesia 49:877-879 (2002)
© Canadian Anesthesiologists' Society, 2002
Cardiothoracic Anesthesia, Respiration and Airway

High-dose colforsin daropate increases diaphragmatic contractility in dogs

[De fortes doses de daropate de colforsine augmentent la contractilité diaphragmatique chez les chiens]

Yoshitaka Fujii, MD and Hidenori Toyooka, MD

From the Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, Tsukuba City, Ibaraki, Japan.

Dr. Y. Fujii, Department of Anesthesiology, University of Tsukuba Institute of Clinical Medicine, 2-1-1, Amakubo, Tsukuba City, Ibaraki 305-8576, Japan. Phone: +81-298-53-3763; Fax: +81-298-53-3765; E-mail yfujii{at}igaku.md.tsukuba.ac.jp

Purpose: To evaluate the effects of colforsin daropate, a water-soluble derivate known to improve contractility in fatigued canine diaphragm, at two different doses (low-dose and high-dose) on contractility of the non-fatigued diaphragm of dogs.

Methods: Twenty-four pentobarbitone-anesthetized dogs were divided into three groups of eight each: Group I received no study drug; Group II received low-dose (0.2 µg•kg-1•min-1) colforsin daropate; Group III received high-dose (0.5 µg•kg-1•min-1) colforsin daropate. Diaphragmatic contractility was assessed by transdiaphragmatic pressure (Pdi).

Results: In Group III, with an infusion of high-dose colforsin daropate, Pdi at low-frequency (20 Hz) and high-frequency (100 Hz) stimulation increased from baseline values (P < 0.05). Compared with Group I, Pdi at both stimuli increased during colforsin daropate administration in Group III (P < 0.05). In Group II, with an infusion of low- dose colforsin daropate, Pdi to each stimulus did not change.

Conclusion: Colforsin daropate, only when administered at high-dose, increases contractility of non-fatigued diaphragm in dogs.






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Copyright © 2002 by the Canadian Anesthesiologists' Society.