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Canadian Journal of Anesthesia, Vol 5, 35-40, Copyright © 1958 by Canadian Anesthesiologists' Society
1 Clinical Teacher, Department of Anaesthesia, University of Toronto
A mixture of chlorpromazine, promethazine and Demerol was administered intramuscularly as sedation to 670 children undergoing cardiac catheterization.
With certain modifications, an arbitrary dosage schedule of 1 cc/20 lb. was employed. Infants in poor condition or with cyanosis received 50–80 per cent of this arbitrary dose. A maximum dose of 1.5 cc was used in patients weighing more than 30 pounds. Those patients who were insufficiently sedated were supplemented with small diluted quantities of the mixture given via the catheter. Such injections should be made into a vena cava rather than into a chamber of the heart.
Details of four deaths occurring in the per-catheter and post-catheter periods are presented.
Note:
From the Departments of Anaesthesia and Paediatrics, University of Toronto and the Hospital for Sick Children, Toronto
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