CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by MAYKUT, M. O.
Right arrow Search for Related Content
PubMed
Right arrow Articles by MAYKUT, M. O.

Canadian Journal of Anesthesia, Vol 5, 161-169, Copyright © 1958 by Canadian Anesthesiologists' Society

The Combined Action of Pentobarbital and Meperidine, and of Procaine and Meperidine, in Guinea Pigs

MADELAINE O. MAYKUT PH.D.1

1 Department of Pharmacology, University of Toronto

Meperidine increases the sleeping time induced by pentobarbital in guinea pigs.

The effect of pentobarbital on the toxicity of meperidine was antagonistic, whereas the effect of meperidine on the toxicity of pentobarbital was nearly additive.

The results of these experiments show that pentobarbital will protect experimental animals against the convulsive effects of meperidine and that the depressant action of pentobarbital is augmented by the presence of meperidine. It has been pointed out that when meperidine and procaine are combined there is a potentiation of convulsive effects, but their combined lethal effects, while greater than that of either one alone, are not additive.

Note:

The data included herein were taken partly from a Thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy, University of Toronto, May, 1957.






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1958 by the Canadian Anesthesiologists' Society.