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Canadian Journal of Anesthesia, Vol 5, 170-176, Copyright © 1958 by Canadian Anesthesiologists' Society

Adrenergic Blocking Agents in Shock

WOLFGANG E. SPOEREL M.D., F.R.C.P. (C)1

1 Department of Anaesthesia and Department of Physiology, University of Western Ontario, London, Ont.

Premedication with adrenergic blocking agents in experimental haemorrhagic shock pocedure increases the tolerance to hypotension but diminishes the tolerance to hypovolemia. The experimentally observed protection against irreversible shock by such agents appears to be mainly due to a reduced blood loss, which is technically unavoidable in the experimental procedures usually employed.

There is no experimental evidence that adrenergic blocking agents are of value in the treatment of shock at a time when transfusion therapy fails. There is also no indication that a combination of blocking agents and volume replacement would be superior to blood volume replacement alone.

Note:

Presented at the combined meeting of Section of Anaesthesia, Ontario Medical Association, and the Ontario Division of the Canadian Anaesthetists' Society, October 5, 1957, in Hamilton, Ont.






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Copyright © 1958 by the Canadian Anesthesiologists' Society.