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The therapeutic use of magnesium in anesthesiology, intensive care and emergency medicine: a review

[L’usage thérapeutique du magnésium en anesthésiologie, réanimation et médecine d’urgence]

From the Department of Anesthesiology, University Hospital, Angers, France.

Address correspondence to: Dr. Laurent Dubé, Département d’Anesthésie Réanimation, CHU Angers, 4, rue Larrey, 49033 Angers Cédex 1, France. Phone: 33 2 41 35 36 35; Fax: 33 2 41 35 39 67; E-mail: Ladube{at}chu-angers.fr

Purpose: To review current knowledge concerning the use of magnesium in anesthesiology, intensive care and emergency medicine.

Methods: References were obtained from Medline® (1995 to 2002). All categories of articles (clinical trials, reviews, or meta-analyses) on this topic were selected. The key words used were magnesium, anesthesia, analgesia, emergency medicine, intensive care, surgery, physiology, pharmacology, eclampsia, pheochromocytoma, asthma, and acute myocardial infarction.

Principal findings: Hypomagnesemia is frequent postoperatively and in the intensive care and needs to be detected and corrected to prevent increased morbidity and mortality. Magnesium reduces catecholamine release and thus allows better control of adrenergic response during intubation or pheochromocytoma surgery. It also decreases the frequency of postoperative rhythm disorders in cardiac surgery as well as convulsive seizures in preeclampsia and their recurrence in eclampsia. The use of adjuvant magnesium during perioperative analgesia may be beneficial for its antagonist effects on N-methyl-D-aspartate receptors. The precise role of magnesium in the treatment of asthmatic attacks and myocardial infarction in emergency conditions needs to be determined.

Conclusions: Magnesium has many known indications in anesthesiology and intensive care, and others have been suggested by recent publications. Because of its interactions with drugs used in anesthesia, anesthesiologists and intensive care specialists need to have a clear understanding of the role of this important cation.

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