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Canadian Journal of Anesthesia 50:830-834 (2003)
© Canadian Anesthesiologists' Society, 2003
Cardiothoracic Anesthesia, Respiration and Airway

Milrinone attenuates the negative inotropic effects of landiolol in halothane-anesthetized dogs

[La milrinone atténue les effets inotropes négatifs du landiolol chez des chiens anesthésiés avec de l’halothane]

Shinji Takahashi, MD, Yoshitaka Fujii, MD, Takuo Hoshi, MD, Aki Uemura, MD, Masayuki Miyabe, MD and Hidenori Toyooka, MD

From the Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Japan.

Address correspondence to: Dr. Shinji Takahashi, Department of Anesthesiology, Institute of Clinical Medicine, University of Tsukuba, Tenodai 1-1-1, Tsukuba-city 305-8575, Japan. Phone and FAX: 81-29-853-3092; E-mail: shinjitk{at}md.tsukuba.ac.jp

Background: Clinical use of high dose beta-blocker therapy is limited by excessive negative inotropic effects. Previous studies suggest that milrinone may be of utility in limiting the inotropic but not the chronotropic effects of beta blockers. We examined the hemodynamic effects of co-administration of a new potent selective beta1 blocker, landiolol, and milrinone in halothane-anesthetized dogs.

Methods: Eighteen adult mongrel dogs were anesthetized with 1.2 MAC halothane. Hemodynamic measurements were made at baseline, 30 min after starting the milrinone (0.5 µg•kg-1•min-1) or normal saline infusion (n = 9 in each), then 30 min after each change in the dose of landiolol infusion. The tested doses of landiolol were 10, 100, and 1000 µg•kg-1•min-1.

Results: Landiolol (>= = 10 µg•kg-1•min-1) has significant and comparable negative chronotropic effects in both groups of dogs. While it also has significant negative inotropic effects in both groups, such effects are significantly attenuated in the dogs treated with milrinone.

Conclusion: Milrinone is effective to attenuate the negative inotropic effects of landiolol in halothane-anesthetized dogs.






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