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Canadian Journal of Anesthesia 51:668-671 (2004)
© Canadian Anesthesiologists' Society, 2004
General Anesthesia

Oral tandospirone and clonidine provide similar relief of preoperative anxiety

[L’administration orale de tandospirone ou de clonidine fournit un soulagement similaire de l’anxiété préopératoire]

Aya Iizawa, MD, Tsutomu Oshima, MD, Yoshiko Kasuya, MD and Shuji Dohi, MD

From the Department of Anesthesiology, Gifu University School of Medicine, Gifu, Japan.

Address correspondence to: Dr. Tsutomu Oshima, Department of Anesthesiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu City, Gifu 501-1194, Japan. Phone: 81-58-230-6404, Fax: 81-58-230-6405, E-mail: oshimat{at}cc.gifu-u.ac.jp

Purpose: To compare oral tandospirone with oral clonidine in terms of preoperative anxiolysis.

Methods: Preoperative anxiety was measured using the Spielberger state-trait anxiety inventory (STAI-state). Pretreatment evaluation was performed on the day before surgery and post-treatment examination immediately after entry into the operating room. In a double-blind, randomized design, three groups of 40 patients received one of the following oral medications 90 min before entry into the operating room: 1) tandospirone 10 mg (T group); 2) clonidine 3 µg·kg–1 (C group); or 3) placebo (P group).

Results: Following premedication, the STAI-state decreased in the T group (P < 0.05) while exhibiting no significant changes in the C group. As far as the changes in the STAI-state were concerned, however, the P-group was different from each of the other groups (P < 0.05 vs T group and vs C group).

Conclusion: Oral tandospirone was equivalent to oral clonidine in terms of reduction in preoperative anxiety.






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Copyright © 2004 by the Canadian Anesthesiologists' Society.