This Article Résumé de cet Article Full Text Full Text (PDF) Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Saitoh, Y. Articles by Murakawa, M. Search for Related Content PubMed PubMed Citation Articles by Saitoh, Y. Articles by Murakawa, M.

Delayed recovery of vecuronium neuromuscular block in diabetic patients during sevoflurane anesthesia

[Bloc neuromusculaire au vécuronium prolongé chez des patients diabétiques pendant l’anesthésie au sévoflurane]

Yuhji Saitoh, MD^*, Hisashi Hattori, MD, Norie Sanbe, MD, Hiroshi Nakajima, MD, Masahiko Akatu, MD and Masahiro Murakawa, MD

^* From the Department of Anesthesiology, Saitama Medical School, Saitama; and
the Department of Anesthesiology, Fukushima Medical University School of Medicine, Fukushima, Japan.

Address correspondence to: Dr. Yuhji Saitoh, Saitama Medical School Department of Anesthesiology, 38, Morohongo, Moroyama, Iruma-gun, Saitama, 350-0495, Japan. Phone: +81-49-276-1271; Fax +81-49-295-8077; E-mail: ysys{at}r5.dion.ne.jp

Purpose: To study recovery from vecuronium-induced neuromuscular block in diabetic patients during total iv or sevoflurane anesthesia.

Methods: 30 diabetic patients were assigned to diabetes mellitus (DM)-total iv anesthesia (TIVA); (n = 15) or DM-sevoflurane (S) groups (n = 15). Thirty healthy patients were divided into control-TIVA (n = 15) or control-S groups (n = 15). In the DM-TIVA or control-TIVA groups and DM-S or control-S groups, anesthesia was maintained with propofol and fentanyl, and nitrous oxide-oxygen-sevoflurane 1.7%, respectively. After receiving vecuronium 0.1 mg·kg^–1iv, recovery of the train-of-four (TOF) was compared among the four groups.

Results: Times to the return of T2, T3, or T4 in the DM-TIVA and DM-S groups were longer than in the control-TIVA and control-S groups (46.9 ± 13.8 vs 32.2 ± 10.7 and 32.6 ± 8.7 min for T2, P < 0.05). T1/control in the DM-S group was less than in the control-TIVA and DM-TIVA groups 50 to 120 and 70 to 120 min after receiving vecuronium, respectively (P < 0.05). T1/control in the control-S group was less than in the control-TIVA group 80 to 120 min after receiving vecuronium (P < 0.05). TOF ratio in the DM-S group was less than in the control-TIVA, DM-TIVA, and control-S groups, 60 to 120, 80 to 120, and 80 to 120 min after receiving vecuronium, respectively (P < 0.05).

Conclusion: In diabetic patients receiving vecuronium, recovery of T1/control and TOF ratio are delayed during sevoflurane anesthesia, but not in association with total iv anesthesia.

This article has been cited by other articles:

				Y. Saitoh Recovery from vecuronium is delayed in patients with hypercholesterolemia: [La recuperation d'un bloc au vecuronium est retardee en cas d'hypercholesterolemie]. Can J Anesth, June 1, 2006; 53(6): 556 - 561. [Abstract] [Full Text] [PDF]