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Canadian Journal of Anesthesia 52:710-716 (2005)
© Canadian Anesthesiologists' Society, 2005
Regional Anesthesia and Pain

L’analgésie péridurale thoracique et rachidienne ont des effets comparables sur la douleur et la fonction respiratoire après chirurgie thoracique

[Thoracic epidural and intrathecal analgesia have similar effects on pain relief and respiratory function after thoracic surgery]

Samia Madi-Jebara, MD, Céline Adaimé, MD, Alexandre Yazigi, MD, Fadia Haddad, MD, Gemma Hayek, MD, Ghassan Sleilaty, MD and Marie-Claire Antakly, MD

Du Département d’Anesthésie-Réanimation, Hôpital Hôtel-Dieu de France, Beyrouth, Liban.

Adresser la correspondence à: Dr Samia Madi-Jebara, Département d’Anesthésie-Réanimation, Hôpital Hôtel-Dieu de France, Beyrouth, Liban. Téléphone : 961 3272747 ; Télécopieur : 961 1426181 ; Courriel : vix{at}dm.net.lb

Purpose: To compare in a prospective randomized trial the effects of thoracic epidural infusions of fentanyl (F) and bupivacaine (B) to intrathecal morphine (M) and sufentanil (S) on analgesia and respiratory function following thoracotomy.

Patients and methods: 55 patients undergoing an elective postero-lateral thoracotomy were randomly assigned to one of two groups: Group I (n = 27): received intrathecal S (5 µg) and M (0.5 mg) one hour before surgery. Group II (n = 28) received, after induction of anesthesia, an initial dose of 10 to 20 mL of a solution of B 0.25% and F 2 µg·mL–1 via an epidural thoracic catheter previously inserted between T5 and T8. The same solution was infused during surgery. After surgery, patients received a continuous infusion of B 0.1% and F 2 µg·mL–1 with a bolus every 15 min if needed. Heart rate (HR), mean arterial pressure (MAP), SpO2, PaCO2, respiratory rate (RR), forced expiratory volume in one second, peak expiratory flow rate and forced vital capacity were recorded at different times from the day before surgery till T48 = 48 hr after surgery. Subjective pain was assessed using a 10 cm visual analogue scale (VAS) scoring at rest and during cough.

Results: No significant difference was noted between both groups concerning VAS, HR, MAP, SpO2, PaCO2 and RR. Variations of the respiratory function tests were identical in both groups.

Conclusion: This study shows that intrathecal M and S offer analgesia comparable to thoracic epidural infusion of B and F.






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