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Xenon does not modify mivacurium induced neuromuscular block

[Le xénon ne modifie pas le bloc neuromusculaire induit par le mivacurium]

From the Department of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany.

Address correspondence to: Dr. Oliver Kunitz, Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, D-52074 Aachen, Germany. Phone: +49-241-8088179; Fax: +49-241-8082406; E-mail: oliver.kunitz{at}mutterhaus.de

Purpose: The interaction between mivacurium and inhaled anesthetics is known, with the exception of xenon. We compared the pharmacodynamics of mivacurium during xenon anesthesia vs total iv anesthesia with propofol.

Methods: This randomized controlled trial was carried out in the Aachen University Hospital. Forty-two adult patients ASA I or II, aged 18 to 60 yr, were randomized to receive either xenon or propofol anesthesia. Anesthesia was induced with propofol and remifentanil in both groups (each n = 21). The xenon group received xenon via facemask until an end-expiratory concentration of 60% was reached for one minute. Meanwhile, the acceleromyograph was calibrated and a train-of-four stimulation of the adductor pollicis muscle was started. After stabilization of the signal for five minutes, a single bolus of 0.16 mg·kg–1 mivacurium was injected. Anesthesia was maintained with xenon and remifentanil or with propofol and remifentanil.

Results: There were no significant differences between groups with respect to onset time (xenon 180 ± 64 vs propofol 195 ± 77 sec; P = 0.39), duration (xenon 16.18 ± 4.97 vs propofol 15.68 ± 6.17 min; P = 0.73), recovery index (xenon 5.63 ± 2.48 vs propofol 5.73 ± 2.12 min; P = 0.42) and clinical recovery (xenon 8.75 ± 2.57 vs propofol 9.28 ± 2.28 min; P = 0.22).

Conclusion: We conclude that the neuromuscular blocking effects of mivacurium are similar when given during propofol vs xenon anesthesia.

This article has been cited by other articles:

				M. Coburn, O. Kunitz, C. C. Apfel, M. Hein, M. Fries, and R. Rossaint Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia Br. J. Anaesth., June 1, 2008; 100(6): 787 - 791. [Abstract] [Full Text] [PDF]