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Canadian Journal of Anesthesia 53:1180-1185 (2006)
© Canadian Anesthesiologists' Society, 2006
Regional Anesthesia and Pain

Protective effect of prior administration of magnesium on delayed hyperalgesia induced by fentanyl in rats

[L’effet protecteur de l’administration préalable de magnésium sur l’hyperalgésie secondaire produite par le fentanyl chez le rat]

Alain C. Van Elstraete, MD, Philippe Sitbon, MD, Jean-Xavier Mazoit, MD PhD, Marc Conti, PharmD PhD and Dan Benhamou, MD

From the Department of Anesthesiology and Biochemistry Laboratory, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, and the Anesthesia Laboratory UPRES-EA3540, Faculté de Médecine du Kremlin-Bicêtre Université Paris-Sud, Le Kremlin-Bicêtre, France.

Address correspondence to: Dr. Van Elstraete, Service d’Anesthésie-Réanimation, Hôpital de Bicêtre, 94275 Le Kremlin-Bicêtre, France. Phone: +(33) 145213441; Fax: +(33) 145212875; E-mail: alainvanel{at}hotmail.com

Purpose: Magnesium exerts a physiological block of the ion channel on the N-methyl-D-aspartate receptor, and may therefore prevent the induction of central sensitization. The purpose of this study was to assess whether systemic magnesium can prevent long-lasting hyperalgesia induced by sc fentanyl administration in uninjured rats.

Methods: Long-lasting hyperalgesia was induced in male Sprague Dawley rats with sc fentanyl (four injections, 60 µg·kg–1 per injection at 15-min intervals). Magnesium sulphate (100 mg·kg–1) was injected ip 30 min prior to the first sc fentanyl injection. Sensitivity to nociceptive stimuli (paw-pressure test) was assessed for several days after injections.

Results: Subcutaneous fentanyl led to delayed hyperalgesia associated with a decrease in the nociceptive threshold lasting two days (35% decrease for the maximum effect). Intraperitoneal magnesium sulphate partially but significantly (P < 0.05) prevented the delayed decrease in the nociceptive threshold following sc administration of fentanyl.

Conclusions: This study shows that magnesium may prevent the delayed and prolonged hyperalgesia following fentanyl administration in rats.






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