This Article Résumé de cet Article Full Text Full Text (PDF) An erratum has been published Submit a scholarly reply Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Related articles in CJA Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Rodríguez-López, J. M. Articles by Muriel, C. Search for Related Content PubMed PubMed Citation Articles by Rodríguez-López, J. M. Articles by Muriel, C.

Laboratory investigation: Effects of propofol on the systemic inflammatory response during aortic surgery

[Essai en laboratoire : les effets du propofol sur la réaction inflammatoire généralisée pendant une opération de l’aorte]

José M. Rodríguez-López, MD^*, Pilar Sánchez-Conde, MD^*, Francisco S. Lozano, MD, Juan L. Nicolás, MBBS, Francisco J. García-Criado, MD, Carlos Cascajo, MD and Clemente Muriel, MD^*

^* From the Departments of Anesthesiology, and
Surgery, University Hospital of Salamanca, Salamanca; and the
Department of Anesthesiology, Rodríguez-Chamorro Hospital, Zamora, Spain.

Address correspondence to: Dr. José María Rodríguez-López, Servicio de Anestesiología, Hospital Universitario de Salamanca, Paseo de San Vicente, 58-182, 37007, Salamanca, Spain. Phone: 0034-923291353; E-mail: jmrodlop{at}terra.es

Purpose: A laboratory investigation was undertaken to assess the effects of propofol on renal function, through modulation of the systemic inflammatory response, in an in vivo experimental model of aortic surgery in comparison with sevoflurane.

Methods: Twenty young male piglets were anesthetized with either propofol 4 mg·kg^–1·hr^–1 (n = 10) or sevoflurane 1.5% end-tidal concentration (n = 10). Animals were subjected to aorta-aortic bypass with suprarenal aortic clamping for 30 min. At specific intervals (basal -before the start of surgery; reperfusion 15 min after unclamping the aorta; at 24, 48 and 72 hr after surgery, and on the seventh day after surgery) the levels of the following were determined: plasma creatinine, renal myeloperoxidase, tumour necrosis factor-, interleukin 1-ß, and interferon-; kidney superoxide anion and its detoxifying enzyme superoxidase dismutase, kidney malondialdehyde and the activity of inducible nitric oxide synthase. Seven days after surgery, the animals were anesthetized using the described techniques, and after blood withdrawal and kidney sampling they were sacrificed.

Results: In comparison with sevoflurane, propofol was associated with a lower concentration of plasma creatinine (P < 0.05) together with lower concentrations of myeloperoxidase, tumour necrosis factor-, interleukin 1-ß, interferon-, superoxide anion and superoxidase dismutase, malondialdehyde and inducible nitric oxide synthase (P < 0.05).

Conclusion: In an experimental model of aortic reconstructive surgery, and compared with sevoflurane, propofol anesthesia is associated with less neutrophil infiltration, lower plasma proinflammatory cytokine levels, lower production of oxygen free radicals, less lipid peroxidation, and reduced inducible nitric oxide synthase activity. These observations suggest a possible renal protective effect of propofol in this surgical setting.

Related articles in CJA:

Is anesthesia good for you? Timing is everything!/L’anesthésie est-elle bonne pour vous ? Tout est dans le bon moment !

David M. Ansley
CJA 2006 53: 643-645. [Full Text]  

This article has been cited by other articles:

				P. Sanchez-Conde, J. M. Rodriguez-Lopez, J. L. Nicolas, F. S. Lozano, F. J. Garcia-Criado, C. Cascajo, R. Gonzalez-Sarmiento, and C. Muriel The Comparative Abilities of Propofol and Sevoflurane to Modulate Inflammation and Oxidative Stress in the Kidney After Aortic Cross-Clamping Anesth. Analg., February 1, 2008; 106(2): 371 - 378. [Abstract] [Full Text] [PDF]

				S. Fukuda and D. S. Warner Cerebral protection Br. J. Anaesth., July 1, 2007; 99(1): 10 - 17. [Abstract] [Full Text] [PDF]

				Z. Xia, H.-m. Liu, and Q.-z. Tang Does propofol suppress nitrosative stress during aortic surgery in pigs? Can J Anesth, December 1, 2006; 53(12): 1267 - 1268. [Full Text] [PDF]

				D. M. Ansley Is anesthesia good for you? Timing is everything!/L'anesthesie est-elle bonne pour vous ? Tout est dans le bon moment ! Can J Anesth, July 1, 2006; 53(7): 643 - 645. [Full Text] [PDF]