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Laryngopharyngeal mucosal injury after prolonged use of the ProSeal^TM LMA in a porcine model: a pilot study

[Lésion de la muqueuse laryngo-pharyngée suite à une utilisation prolongée du masque laryngé ProSeal^TM dans un modèle porcin: une étude pilote]

Kai Goldmann, MD DEAA^*, Joerg Dieterich, RN^* and Marion Roessler, MD

^* From the Department of Anaesthesia and Intensive Care Therapy, and the
Department of Pathology, Philipps University Marburg, Marburg, Germany.

Address correspondence to: Dr. Kai Goldmann, Department of Anaesthesia and Intensive Care Therapy, University Clinic Giessen-Marburg, Campus Marburg, Philipps University Marburg, 35033 Marburg, Germany. Phone: +49 6421 2862516; Fax: +49 6421 2866996; E-mail: kaigoldmann1{at}aol.com

Purpose: Little is known about the potential for the cuff of the ProSeal^TM laryngeal mask airway (PLMA) to cause laryngopharyngeal mucosal injury. The aim of this study was to investigate the effects of prolonged exposure of the laryngopharyngeal mucosa to the PLMA in an animal model.

Methods: The PLMA was used for positive pressure ventilation in eight German country pigs randomized to receive different durations of anesthesia lasting three to 24 hr. Two additional pigs served as controls. Biopsies from 14 predetermined areas of the laryngopharyngeal mucosa were examined histopathologically using light microscopy. The number of areas with signs of mucosal damage was evaluated, and the degree of tissue damage was analyzed using a semiquantitative scoring system.

Results: The number of areas with moderate to severe mucosal damage was 0–2 in animals anesthetized for less than 12 hr, 6 in animals anesthetized for 12–18 hr, and 12 in animals anesthetized for more than 18 hr. The severity of mucosal damage was also time-dependent, indicated by raising semiquantitative scores for epithelial and subepithelial mucosal damage.

Conclusion: The histopathological findings of this study show that prolonged use of the PLMA in the pig for up to nine hours is associated with no, or only mild alterations in the laryngopharyngeal mucosa, whereas use for 12 hr or more is associated with clear signs of mucosal injury.

Related articles in CJA:

ProSeal LMA – how long is too long?/Le LMA ProSeal – Combien de temps est trop long?

Richard M. Cooper
CJA 2007 54: 786-789. [Full Text]  

This article has been cited by other articles:

				R. M. Cooper ProSeal LMA how long is too long?/Le LMA ProSeal Combien de temps est trop long? Can J Anesth, October 1, 2007; 54(10): 786 - 789. [Full Text] [PDF]