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* From the Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China; and the
Department of Anesthesia and Pain Management, Toronto General Hospital, University of Toronto, Toronto, Ontario, Canada.
Address correspondence to: Dr. Chaozhi Luo, Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu Sichuan Province, 610041, China. Phone: 86-28-85423593; Fax: 86-28-85423591; E-mail: xwtao_zhu{at}yahoo.com
Purpose: Propofol has been reported to alter hepatic blood flow and to increase hepatic oxygen consumption. This study was designed to determine the effect of propofol on hepatic blood flow and oxygenation in rabbits, in order to establish its net effect on hepatic oxygen balance.
Methods: Twenty, adult male, New Zealand white rabbits were randomly divided into two groups: Group P (propofol, 0.6 mg·kg–1·min–1) or Group C (10% intralipid, 0.6 mg·kg–1·min–1). An electromagnetic flowmeter was used to measure hepatic blood flow, and blood, from the carotid artery, the portal vein, and the hepatic vein, was used to determine hepatic oxygenation. After we obtained baseline values, we repeated measurements ten, 30, and 60 min after initiating the infusion.
Results: Intralipid did not affect systemic hemodynamics, hepatic blood flow, or oxygenation during the 60 min infusion; however, propofol caused a time-dependent decrease in mean arterial blood pressures and an increase in portal venous flow and total hepatic blood flow. In contrast, hepatic arterial blood flow remained unchanged during the propofol infusion. Hepatic oxygen delivery and consumption increased in a time-dependent manner to maximums of 25% and 21.4% (both, P < 0.05) above baseline, respectively. Hepatic venous oxygen saturation and extraction was unchanged throughout the study period.
Conclusion: Propofol increases total hepatic blood flow, primarily by increasing hepatic portal venous flow. The increase in liver oxygen consumption was fully compensated by an increase in oxygen supply to the liver, resulting in a preserved, hepatic oxygen balance.
1 Fukuda I, Uchihashi Y, Kira M, et al. Effects of propofol on hepatic venous oxygen saturation – a comparison with isoflurane or sevoflurane anesthesia (Japanese). Masui 2005; 54: 736–41.[Medline]
2 Armbruster K, Noldge-Schomburg GF, Dressler IM, Fittkau AJ, Haberstroh J, Geiger K. The effects of desflurane on splanchnic hemodynamics and oxygenation in the anesthetized pig. Anesth Analg 1997; 84: 271–7.[Abstract]
3 Leslie K, Sessler DI, Bjorksten AR, Moayeri A. Mild hypothermia alters propofol pharmacokinetics and increases the duration of action of atracurium. Anesth Analg 1995; 80: 1007–14.[Abstract]
4 Carmichael FJ, Crawford MW, Khayyam N, Saldivia V. Effect of propofol infusion on splanchnic hemodvnamics and liver oxygen consumption in the rat. A dose-response study. Anesthesiology 1993; 79: 1051–60.[Medline]
5 Haberer JP, Audibert G, Saunier CG, Muller C, Laxenaire MC, Hartemann D. Effect of propofol and thiopentone on regional blood flow in brain and peripheral tissues during normoxia and hypoxia in the dog. Clin Physiol 1993; 13: 197–207.[Medline]
6 Runciman WB, Mather LE, Selby DG. Cardiovascular effects of propofol and of thiopentone anaesthesia in the sheep. Br J Anaesth 1990; 65: 353–9.
7 Lange H, Stephan H, Rieke H, Kellerman M, Sonntag H, Bircher J. Hepatic and extrahepatic disposition of propofol in patients undergoing coronary bypass surgery. Br J Anaesth 1990; 64: 563–70.
8 Doursout MF, Joseph PM, Liang YY, Hartley CJ, Chelly JE. Role of propofol and its solvent, intralipid, in nitric oxide-induced peripheral vasodilatation in dogs. Br J Anaesth 2002; 89: 492–8.
9 Raisis AL. Skeletal muscle blood flow in anaesthetized horses. Part I: measurement techniques. Vet Anaesth Analg 2005; 32: 324–30.[Medline]
10 Leevy CM, Bender J. Physiology of dye extraction by the liver: comparative studies of sulfobromophthalein and indocyanine green. Ann N Y Acad Sci 1963; 111: 161–76.[Medline]
11 Chow PK, Yu WK, Soo KC, Chan ST. The measurement of liver blood flow: a review of experimental and clinical methods. J Surg Res 2003; 112: 1–11.[Medline]
12 Noldge GF, Priebe HJ, Kopp KH, Pelchen T, Riegel W, Geiger K. Differences in effects of isoflurane and enflurane on splanchnic oxygenation and hepatic metabolism in the pig. Anesth Analg 1990; 71: 258–67.
13 Simons PJ, Cockshott ID, Douglas EJ, Gordon EA, Knott S, Ruane RJ. Species differences in blood profiles, metabolism and excretion of 14C-propofol after intravenous dosing to rat, dog and rabbit. Xenobiotica 1991; 21: 1243–56.[Medline]
14 Lautt WW. Mechanism and role of intrinsic regulation of hepatic arterial blood flow: hepatic arterial buffer response. Am J Physiol 1985; 249: G549–56.[Medline]
15 Vagts DA, Iber T, Puccini M, et al. The effects of thoracic epidural anesthesia on hepatic perfusion and oxygenation in healthy pigs during general anesthesia and surgical stress. Anesth Analg 2003; 97: 1824–32.
16 Kennedy WF Jr, Everett GB, Cobb LA, Allen GD. Simultaneous systemic and hepatic hemodynamic measurements during high peridural anesthesia in normal man. Anesth Analg 1971; 50: 1069–77.[Medline]
17 Fan SZ, Yu HY, Chen YL, Liu CC. Propofol concentration monitoring in plasma or whole blood by gas chromatography and high-performance liquid chromatography. Anesth Analg 1995; 81: 175–8.[Abstract]
18 Shimono H, Goromaru T, Kadota Y, Tsurumaru T, Kanmura Y. Propofol displays no protective effect against hypoxia/reoxygenation injury in rat liver slices. Anesth Analg 2003; 97: 442–8.
19 Gelman S. General anesthesia and hepatic circulation. Can J Physiol Pharmacol 1987; 65: 1762–79.[Medline]
20 Van Hemelrijck J, Fitch W, Mattheussen M, Van Aken H, Plets C, Lauwers T. Effect of propofol on cerebral circulation and autoregulation in the baboon. Anesth Analg 1990; 71: 49–54.
21 Constandinou C, Henderson N, Iredale JP. Modeling liver fibrosis in rodents. Methods Mol Med 2005; 117: 237–50.[Medline]
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