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Canadian Journal of Anesthesia, Vol 6, 159-168, Copyright © 1959 by Canadian Anesthesiologists' Society

A Reliable Colorimetric Method for the Quantitative Determination of Procaine in Human Whole Blood

MADELAINE O. MAYKUT PH.D.1

1 Department of Pharmacology, University of Toronto, and Shouldice Surgery, Toronto, Ont.

A method which has been developed for the satisfactory estimation of procaine in whole blood avoids the loss of procaine which was apparent in methods where blood proteins were precipitated by use of trichloroacetic acid. Approximately 85 per cent of the added procaine was constantly recovered by this method from test samples of blood and the procedure was considered to be satisfactory for determining concentrations of procaine in patients' blood. The peak concentration of procaine in blood twenty minutes after the infiltration of procaine (2.06–3.7 gm.) varied from 0.7 µg. to 5.0 µg. per gram of blood in the patients studied.

Note:

The data included herein were taken in part from a Thesis submitted in partial fulfilment of the requirements for the degree of Doctor of Philosophy, University of Toronto, May, 1957.






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Copyright © 1959 by the Canadian Anesthesiologists' Society.