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Canadian Journal of Anesthesia, Vol 7, 304-309, Copyright © 1960 by Canadian Anesthesiologists' Society

Halothane-Induced Hypotension and the Effect of Vasopressors

ROBERT W. LOEHNING M.D., PH.D.1 and VASIL P. CZORNY M.D.2

1 Assistant Professor, Division of Anesthesiology, University of Utah
2 Resident in Anesthesiology, Division of Anesthesiology, University of Utah

Seven of eight dogs on fixed-volume ventilati3n and subjected to concentrations of halothane which lowered blood pressure to 20–40 mm. of mercury recovered when the anaesthetic was discontinued and hyperventilation was instituted. None of the dogs developed arrhythmias while hypotension was being induced or as its blood pressure returned to pre-existing level. The remaining animal developed cardiac standstill.

Phenylephrine, methoxamine, and mephntermine administration during hypotension was followed by a high incidence of cardiac irregularities.

Pretreatment of dogs with 1 mg./kg. of atropine did not prevent arrhythmias.

Trimethaphan camphorosulfonate (Arfonad given at the time irregularities occurred produced a fall in blood pressure with a concomitant conversion of the ECG pattern to normal sinus rhythm.






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Copyright © 1960 by the Canadian Anesthesiologists' Society.