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Canadian Journal of Anesthesia, Vol 7, 411-422, Copyright © 1960 by Canadian Anesthesiologists' Society

The Effects of Nitrous Oxide upon Sensory Thresholds

B. DELISLE BURNS 1, J. G. ROBSON 1, and P.J. L. WELT 1

1 Department of Physiology and the Wellcome Research Department of Anaesthesia, McGill University, Montreal

1. Sensory thresholds have been measured in human subjects while breathing 25 per cent nitrous oxide in oxygen.

2. Nitrous oxide produced a significant and sometimes dramatic increase in the thresholds for touch, skin pain, warmth, vision, and hearing.

3. Elevations in proprioceptive thresholds were not significant.

4. It is suggested that the general increase in sensory thresholds produced by nitrous oxide is a sufficient explanation of the disturbances of memory and time sense that have been observed with nitrous oxide inhalation.






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Copyright © 1960 by the Canadian Anesthesiologists' Society.