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Canadian Journal of Anesthesia, Vol 7, 423-428, Copyright © 1960 by Canadian Anesthesiologists' Society

Induced Sympathetic Stimulation during Halothane Anaesthesia

R. A. MILLAR M.D. (EDIN.), M.SC., F.F.A.R.C.S.1 and M. E. MORRIS M.D.C.M.1

1 Department of Anaesthesia, Montreal Neurological Institute, and McGill University, Montreal, P.Q.

In an attempt to assess the sympatho-adrenal responses to hypercarbia and haemorrhage during halothane anaesthesia, plasma adrenalin and noradrenalin concentrations were determined in dogs maintained in a steady state of anaesthesia by ventilation with 2 per cent halothane in oxygen. During uncomplicated halothane anaesthesia no significant increase or decrease in adrenalin or noradrenalin could be measured. Elevation of arterial pCO2 was accompanied by significant rises in plasma catecholamine levels; mean arterial blood pressure was reduced during hypercarbia. Haemorrhage induced variable increases in adrenalin, with less effect on noradrenalin. The results indicate that depression of sympathetic activity canaot be assumed to occur during surgical anesthesia with halothane.






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Copyright © 1960 by the Canadian Anesthesiologists' Society.