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Canadian Journal of Anesthesia, Vol 8, 118-127, Copyright © 1961 by Canadian Anesthesiologists' Society

The Influence of Exercise on the Neuromuscular Activity of Relaxant Drugs

FRANCIS F. FOLDES 1, ALMIRO P. MONTE 1, H. M. BRUNN Jr. 1, and BERNARD WOLFSON 1

1 Department of Anesthesiology, Mercy Hospital, and the Section on Anesthesiology, Department of Surgery, University of Pittsburgh School of Medicine, Pittsburgh, Penn.

1. The influence of the rate of exercise on the partial neuromuscular block produced by three non-depolarizing (d-Tc, toxiferine, and gallamine) and two depolarizing (CIO and SCh) relaxants was studied in ten healthy, adult, unanaesthetized subjects equally divided between the two sexes.

2. Exercise, which consisted of squeezing the bulb of an ergograph at the rate of six per minute, had no effect on the partial neuromuscular block, as measured by the grip strength, produced by either non-depolarizing or depolarizing relaxants.

3. Similar exercise, but at the rate of 60 per minute, caused a rapid decrease of the grip strength if the partial neuromuscular block was induced by a non-depolarizing agent. No fatigue was observed under similar circumstances if the partial neuromuscular block was induced by a depolarizing relaxant.

4. Possible explanation of the findings presented and their clinical significance have been discussed.

Note:

Read at the Second World Congress of Anaesthesiologists, Toronto, September, 1960.






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Copyright © 1961 by the Canadian Anesthesiologists' Society.