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Canadian Journal of Anesthesia, Vol 8, 154-158, Copyright © 1961 by Canadian Anesthesiologists' Society

The Antisialogogue Effect of Trimethobenzamide HCL (Tigan®), Trimeprazine Tartrate (Panectyl®), Diphenhy-Dramine HCL (Benadryl®), Dimenhydrinate (Gravol®, Dramamine®), and Cyclizine Lactate (Marzine®, Marazine®)

ALLEN B. DOBKIN 1 and V. GUY CRISWICK 2

1 Present address: Department of Anesthesia, University Hospital, Syracuse, New York
2 Student Research Assistant from the University of Saskatchewan College of Medicine

The effect of intravenous trimethobenzamide, trimeprazine, diphenhydramine, dimenhydrinate, and cyclizine on salivary secretion was studied in eight healthy male adult subjects. A mixture of carbaminoylcholine chloride was used to stimulate secretions. The dose selected for each drug was that used for an optimum therapeutic activity of its most desirable effect.

Cyclizine was the most effective antisialogogue of this group, and it also caused moderate drowsiness. Trimeprazine, diphenhydramine, and dimenhydrinate exceeded 50 per cent effectiveness as antisialogogues, and caused varying degrees of drowsiness.

Trimethobenzamide was not effective as an antisialogogue, and did not cause any other objective effects.

Note:

From the Department of Anaesthesia, University Hospital, University of Saskatchewan, Saskatoon, Sask.






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Copyright © 1961 by the Canadian Anesthesiologists' Society.