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Canadian Journal of Anesthesia, Vol 8, 265-269, Copyright © 1961 by Canadian Anesthesiologists' Society

Potentiation of Thiopental Anaesthesia: with Tigan®, Panectyl®, Benadryl®, Gravol®, Marzine®, Histadyl®, Librium®, and Haloperidol (R 1625)

ALLEN B. DOBKIN M.D.1

1 Department of Anaesthesia and Anaesthesia Research Laboratory, University of Saskatchewan College of Medicine

A standardized cross-over experiment was used on dogs with three recently introduced drugs—Tigan (anti-emetic), Librium (neurosedative), and Haloperidol (psychosedative and anti-emetic)—to determine whether they affect the duration of thiopental narcosis. These were compared with some antihistaminic and anti-emetic drugs (Panectyl, Benadryl, Gravol, Marzine, and Histadyl). The dose selected for each drug was based on clinical experience and was adjusted if necessary so that severe cardiorespiratory depression would not occur when they were administered after thiopental.

Tigan had no effect on thiopental narcosis. Histadyl caused only slight prolongation. Librium caused very marked prolongation. The other drugs caused slight to moderate prolongation of thiopental narcosis.

Note:

Present address: Department of Anesthesiology, University Hospital, Upstate Medical Center, Syracuse, New York.






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Copyright © 1961 by the Canadian Anesthesiologists' Society.