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Canadian Journal of Anesthesia, Vol 8, 449-457, Copyright © 1961 by Canadian Anesthesiologists' Society

Studies with Intra-Arterial Succinylcholine and its Hydrolysis Products

JOHN C. ROBERTS M.D.1 and DAVID M. LITTLE JR. M.D.2

1 Present address: Addison Gilbert Hospital, Gloucester, Mass., U.S.A.
2 Department of Anesthesiology, Hartford Hospital Hartford 15, Conn., U.S.A.

In view of experimental work that has pointed to an effect of choline at the neuromuscular junction, and in view of the release of this chemical in the circulatory bed and tissue spaces upon hydrolysis of succinyldicholine, experiments have been conducted to investigate the possible interaction of choline with succinyldicholine.

The experimental conditions obtained were not sufficiently accurate to warrant conclusions as regards the action of choline directly, and the reader is referred to the detailed and careful studies carried out by Hutter15 in England and Grob, Johns, and Harvey in Baltimore14,16 on the action of choline. A marked interaction between choline and subsequently administered succinyldicholine was noted, however, and a hypothesis for the mechanism of action of choline under such circumstances has been presented.

The release of choline by hydrolysis of succinyldicholine and succinylmonocholine is suggested as one cause for prolongation of neuromuscular block during clinical anaesthetic administration of succinylcholine.

Note:

Presented at the Second World Congress of Anaesthesiologists, Toronto, Canada, September 5–10, 1960.






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Copyright © 1961 by the Canadian Anesthesiologists' Society.