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Canadian Journal of Anesthesia, Vol 8, 544-550, Copyright © 1961 by Canadian Anesthesiologists' Society

Methoxyflurane

FERNANDO HUDON M.D., F.R.C.P.(C)1

1 Director, Department of Anaesthesia, Hôtel-Dieu de Québec

Methoxyflurane (Penthrane®) is a new halogenated anaesthetic agent. Induction is slow but smooth. This may be considered as a safety factor. It provides good muscular relaxation. Cardiac rhythm remains stable, so that it may probably be used with epinephrine; our clinical experience confirms that point.

Respiration is depressed by half. Recovery may be prolonged by overpremedication, deep anaesthesia and hypoventilation.

Employed in combination with other anaesthetic agents and curare, and delivered with a precision vaporizer, methoxyflurane permits a faster recovery. Awakening is quiet and without hypotension.

As this drug seems no more toxic than the other inhalation anaesthetic agents it could be useful in anaesthesia in general and in obstetrics in particular.

Note:

Presented at the Annual Meeting of the Canadian Anaesthetists' Society, May 15, 1961.






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Copyright © 1961 by the Canadian Anesthesiologists' Society.