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Canadian Journal of Anesthesia, Vol 9, 42-50, Copyright © 1962 by Canadian Anesthesiologists' Society

Serotonin Release from Carcinoid Tumours

W. P. G. JONES M.B., CH.B.1

1 Department of Anesthesiology, St. Francis Hospital, Milwaukee, Wisconsin

During the course of anaesthesia, in patients with malignant carcinoid disease, sudden episodes of hypotension may occur. These are apparently due to the failure of compensatory mechanisms in the cardiovascular system to adjust rapidly to the effects of sudden serotonin release.

A contributory cause, in long-standing disease, is the development of fibrotic lesions in the heart which impair myocardial efficiency apd lead, eventually, to cardiac failure.

The anaesthetist has a vital role in the maintenance of circulatory homeostasis. He must choose an anaesthetic technique that does not stimulate release of serotonin into the circulation and interferes as little as possible with circulatory physiology. By intelligent anticipation, careful management and strict adherence to well-established anaesthetic principles he can greatly assist a tired and overstrained cardiovascular system in combating the stressful effects of hyperserotoninaemia.






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Copyright © 1962 by the Canadian Anesthesiologists' Society.