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Canadian Journal of Anesthesia, Vol 9, 125-130, Copyright © 1962 by Canadian Anesthesiologists' Society

The Effect of Sympathetic Blockade or Hyperventilation on Epinephrine-Induced Cardiac Arrhythmias during Anaesthesia with Halothane and Methoxyflurane

JACOB S. ISRAEL M.D.1, ALLEN B. DOBKIN M.D.1, and HENRY J. ROBIDOUX Jr B.S.1

1 Anesthesia Research Laboratory, Department of Anesthesiology, State University of New York, Upstate Medical Centre, Syracuse, New York

The effects of high spinal analgesia and hyperventilation on the incidence of epinephrine-provoked cardiac arrhythmias were recorded electrocardiographically on dogs during anaesthesia with 1 % methoxyflurane and with 2 % halothane. It was obvious that neither spinal analgesia nor hyperventilation protects the heart of the dog from the potentially lethal effect of epinephrine when a stable level of anaesthesia is accomplished with methoxyflurane. During halothane anaesthesia, the epinephrine challenges is lethal in most instances.

Note:

Medical Student Research Assistant.






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Copyright © 1962 by the Canadian Anesthesiologists' Society.