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Canadian Journal of Anesthesia, Vol 9, 234-238, Copyright © 1962 by Canadian Anesthesiologists' Society

The Antisialogogue Effect of Hydroxyzine, Thiethylperazine, and N'-p-Chloro-benzylhydryl-N'-methyl Homopiperazine (SA 97)

ALLEN B. DOBKIN M.D.1, HUGH WOODWORTH B.S.1, and JACOB S. ISRAEL M.D.1

1 Department of Anesthesiology, University Hospital, State University of New York, Upstate Medical Center, Syracuse, N.Y., U.S.A.

The volume of salivary secretions from the parotid duct was measured in 10 healthy male subjects in response to intravenous injection of a stimulant mixture containing carbaminoylcholine chloride and epinephrine, and serial tests were carried out to determine whether hydroxyzine, thiethylperazine, and N'-p-chlorobenzylhydryl-N'-methyl homopiperazine (SA 97) have any inhibitory activity in this respect. Only SA 97 had some antisialogogue activity, whereas the other two compounds appeared rather to stimulate salivary secretions. This study again shows that most sedative drugs are unreliable as antisialogogues, and should not be used without a belladonna derivative or some other potent anticholinergic drug, if adequate drying of secretions is desirable.

Note:

Medical student research assistant.






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Copyright © 1962 by the Canadian Anesthesiologists' Society.