CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by DOBKIN, A. B.
Right arrow Articles by CRISWICK, V. G.
Right arrow Search for Related Content
PubMed
Right arrow Articles by DOBKIN, A. B.
Right arrow Articles by CRISWICK, V. G.

Canadian Journal of Anesthesia, Vol 9, 342-346, Copyright © 1962 by Canadian Anesthesiologists' Society

Prolongation of Thiopental Anaesthesia with Hydroxyzine, SA 97, Thiethylperazine, and Thioridazine

ALLEN B. DOBKIN M.D.1, JACOB S. ISRAEL M.D.1, and V. GUY CRISWICK B.S.1

1 Anesthesia Research Laboratory, Department of Anesthesiology, Upstate Medical Center, Syracuse, New York

Four series of crossover experiments were carried out with mongrel dogs to determine whether hydroxyzine and SA 97 (diphenylmethane derivatives) and thiethylperazine and thioridazine (phenothiazine derivatives) prolong sleep induced by thiopental. It was found that hydroxyzine caused prolongation of thiopental sleep, but this effect was not consistet, whereas the other three drugs invariably delayed recovery from thiopental.

When these drugs are used in association with clinical anaesthesia, the slower awakening should be kept in mind in order to avoid the possibility of airway obstruction and pulmonary complications, which often result from delayed return of consciousness.

Note:

Medical student research assistant






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1962 by the Canadian Anesthesiologists' Society.