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Canadian Journal of Anesthesia 47:273-279 (2000)
© Canadian Anesthesiologists' Society, 2000
Laboratory Investigations

Propofol directly depresses lumbar dorsal horn neuronal responses to noxious stimulation in goats

Joseph F. Antognini , MD*, Xiao Wei Wang, MD*, Marla Piercy, BA* and Earl Carstens, PhD{dagger}

* From the Department of Anesthesiology and Pain Management and
{dagger} Section of Neurobiology, Physiology, and Behavior, University of California, Davis, Davis, California USA.

Address correspondence to: Joseph F. Antognini MD, TB-170, University of California, Davis, Davis, CA 95616 USA. Fax: 530-752-7807; E-mail: jfantognini{at}ucdavis.edu

Objectif : Vérifier si le propofol, qui agit sur le cerveau, stimulera les réponses neuronales de la corne supérieure lombaire, ou n'aura aucun effet, après l'application d'un stimulus mécanique nocif aux pattes arrières des chèvres. Les réponses ont été enregistrées pendant l'administration différentielle de propofol au cerveau et à la région thoracique.

Méthode : Les chèvres ont été anesthésiées avec de l'isoflurane et la dissection du cou a été réalisée pour permettre une dérivation crânienne. Une laminectomie a été faite pour faciliter l'enregistrement de l'activité neuronale de la corne supérieure lombaire par microélectrode. L'isoflurane a été maintenu à 0,8 ± 0,1 % à la tête et au tronc tout au long de l'étude. Pendant la dérivation crânienne, le propofol a été administré séparément dans la circulation thoracique (1 mg•kg–1, n=7; 3,75 mg•kg–1, n=8) ou à la tête (0,04 mg•kg–1, n=7; 0,14 mg•kg–1, n=8).

Résultats : Le propofol administré au niveau thoracique a réduit les réponses neuronales à un stimulus nocif: faible dose: 500 ± 243 à 174 ± 240 impulsions•min-1 à une minute postinjection, P < 0.001; forte dose: 478 ± 204 à 91 ± 138 impulsions•min-1 à une minute postinjection, P < 0,05). Le propofol dans la circulation crânienne n'a pas eu d'effet: faible dose: 315 ± 150 à 410 ± 272 impulsions•min-1, P > 0.05; forte dose: 462 ± 261 à 371 ± 196 impulsions•min-1, P > 0,05.

Conclusion : Ces données indiquent que le propofol a un effet dépresseur direct sur les réponses neuronales de la corne supérieure à une stimulation nocive, avec un léger effet supraspinal indirect ou sans effet supraspinal.




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This Article
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