CJA
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pandey, C. K.
Right arrow Articles by Singh, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pandey, C. K.
Right arrow Articles by Singh, P. K.
Canadian Journal of Anesthesia 51:986-989 (2004)
© Canadian Anesthesiologists' Society, 2004
Regional Anesthesia and Pain

Preemptive gabapentin decreases postoperative pain after lumbar discoidectomy

[L’administration préventive de gabapentine diminue la douleur postopératoire d’une discectomie lombaire]

Chandra Kant Pandey, MD, Surabhi Sahay, PDCC, Devendra Gupta, PDCC, Sushil Prakash Ambesh, MD, Ram Badan Singh, PDCC, Mehdi Raza, MD, Uttam Singh, PhD and Prabhat Kumar Singh, MD

From the Departments of Anaesthesiology and Biostatistics, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.

Address correspondence to: Dr. Chandra Kant Pandey, Department of Anaesthesiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow 226014, India. Phone: 0091-522-2668700, ext. 2490; Fax: 0091-522-2668017, attention to Dr. C.K. Pandey; E-mail: ckpandey{at}sgpgi.ac.in

Objectif : Vérifier si l’usage préventif de gabapentine, analogue structurel de l’acide gamma amino-butyrique, pouvait réduire la douleur postopératoire et la consommation de fentanyl dans les cas de discectomie lombaire à un seul niveau.

Méthode : Cinquante-six patients d’état physique ASA I et II, répartis au hasard en deux groupes égaux, ont reçu soit 300 mg de gabapentine, soit un placebo, deux heures avant l’opération. Après l’opération, la douleur a été évaluée selon une échelle visuelle analogique (EVA) de 0–6, 6–12, 12–18 et 18–24 h au repos. La consommation totale de fentanyl pendant les 24 premières heures postopératoires a aussi été notée. Une dose iv de 2 µg·kg–1 de fentanyl a été utilisée pour traiter la douleur postopératoire sur demande.

Résultats : Les patients sous gabapentine ont eu des scores significativement plus bas à l’EVA, pour toutes les mesures aux intervalles de 0–6, 6–12, 12–18 et 18–24 h, que ceux du groupe placebo (3,5 ± 2,3 ; 3,2 ± 2,1 ; 1,8 ± 1,7 ; 1,2 ± 1,3 vs 6,1 ± 1,7 ; 4,4 ± 1,2 ; 3,3 ± 1,1 ; 2,1 ± 1,2 ; P < 0,05). La consommation postopératoire totale de fentanyl pendant les 24 premières heures a été significativement plus faible avec la gabapentine (233,5 ± 141,9, moyenne + écart type) qu’avec le placebo (359,6 ± 104,1 ; P < 0,05).

Conclusion : L’administration préventive de 300 mg po de gabapentine diminue significativement la sévérité de la douleur postopératoire chez les patients qui subissent une discectomie lombaire à un seul niveau.




This article has been cited by other articles:


Home page
 Br J AnaesthHome page
H. J. McQuay, K. H. Poon, S. Derry, and R. A. Moore
Acute pain: combination treatments and how we measure their efficacy
Br. J. Anaesth., July 1, 2008; 101(1): 69 - 76.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
M.-P. Huot, P. Chouinard, F. Girard, M. Ruel, E. R. Lafontaine, and P. Ferraro
Gabapentin does not reduce post-thoracotomy shoulder pain: a randomized, double-blind placebo-controlled study: [La gabapentine ne reduit pas la douleur a l'epaule post-thoracotomie : une etude randomisee, a double insu et controlee par placebo]
Can J Anesth, June 1, 2008; 55(6): 337 - 343.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
A. C. Van Elstraete, M. Tirault, T. Lebrun, I. Sandefo, J.-C. Bernard, B. Polin, P. Vally, and J.-X. Mazoit
The Median Effective Dose of Preemptive Gabapentin on Postoperative Morphine Consumption After Posterior Lumbar Spinal Fusion
Anesth. Analg., January 1, 2008; 106(1): 305 - 308.
[Abstract] [Full Text] [PDF]

Home page
 Br J AnaesthHome page
V. K. F. Kong and M. G. Irwin
Gabapentin: a multimodal perioperative drug?
Br. J. Anaesth., December 1, 2007; 99(6): 775 - 786.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
P. Beaulieu
Non-opioid strategies for acute pain management
Can J Anesth, June 1, 2007; 54(6): 481 - 485.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
E. M. Tiippana, K. Hamunen, V. K. Kontinen, and E. Kalso
Do Surgical Patients Benefit from Perioperative Gabapentin/Pregabalin? A Systematic Review of Efficacy and Safety
Anesth. Analg., June 1, 2007; 104(6): 1545 - 1556.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
F. Adam, C. Menigaux, D. I. Sessler, and M. Chauvin
A Single Preoperative Dose of Gabapentin (800 Milligrams) Does Not Augment Postoperative Analgesia in Patients Given Interscalene Brachial Plexus Blocks for Arthroscopic Shoulder Surgery
Anesth. Analg., November 1, 2006; 103(5): 1278 - 1282.
[Abstract] [Full Text] [PDF]

Home page
 Anesth. Analg.Home page
L. M. Broadman and I. Semenov
The use of "off-label" drugs.
Anesth. Analg., July 1, 2006; 103(1): 250 - 251.
[Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
I. Gilron
Review article: The role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective: [Le role des anticonvulsivants dans le traitement de la douleur postoperatoire : perspective d'une application].
Can J Anesth, June 1, 2006; 53(6): 562 - 571.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
R. K. Seib and J. E. Paul
Preoperative gabapentin for postoperative analgesia: a meta-analysis: [L'administration preoperatoire de gabapentine pour l'analgesie postoperatoire: une meta-analyse].
Can J Anesth, May 1, 2006; 53(5): 461 - 469.
[Abstract] [Full Text] [PDF]

Home page
 Canadian J. AnesthesiaHome page
H. Al-Mujadi, A. R. A-Refai, M. G. Katzarov, N. A. Dehrab, Y. K. Batra, and A. R. Al-Qattan
Preemptive gabapentin reduces postoperative pain and opioid demand following thyroid surgery: [L'administration preventive de gabapentine reduit la douleur postoperatoire et la demande d'opioides a la suite d'une thyroidectomie].
Can J Anesth, March 1, 2006; 53(3): 268 - 273.
[Abstract] [Full Text] [PDF]

This Article
Right arrow Abstract Freely available
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Submit a scholarly reply
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Pandey, C. K.
Right arrow Articles by Singh, P. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Pandey, C. K.
Right arrow Articles by Singh, P. K.

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2004 by the Canadian Anesthesiologists' Society.