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Canadian Journal of Anesthesia 49:A100 (2002)
© Canadian Anesthesiologists' Society, 2002

Abstracts - Tuesday June 25th 2002 1030 - 1230

CAN INHALED NITRIC OXIDE BE EFFECTIVLY DELIVERED TO THE PIGS BRAIN

Driss El-Kebir, PhD*, Tianlong Wang, MD*, Fan Yang, PhD*, Dominique Gauvin, Bsc* and Gilbert Blaise, MD*

* Department of anaesthesia, Hospital Notre-Dame, 1560, Sherbrooke street east, Montreal, Quebec H2L 4M1

INTRODUCTION

Nitric oxide is known to be a potent pulmonary vasodilator and can be transported away from the lung1. Several proteins are possible transporters of NO, which is fixed to thiol groups2. We tested in this study whether inhaled NO can reach the brain in pig model.

MATERIEL AND METHODS

Three male pigs weighing 27, 29 and 30 kg were anesthetized and mechanically ventilated for 8 hours. Cardiovascular and respiratory monitoring were placed. A CSF catheter was placed in the cysterna magna. NOx were measured in CSF samples by chemiluminescence (Sievers).three base values were measured at the beginning of the experimentation and five hours later following ventilation without INO in order to exclude any effect of mechanical ventilation and anesthesia on CSF NOx levels. After 5 hours ventilation without INO, a dose-response to INO was started 20, 40 and 60PPM of INO were administered for one hour, followed by discontinuation of INO for one hour.

RESULTS


CONCLUSION

Diffusion of inhaled Nitric Oxide through the blood-brain barrier seems possible since the concentration of NOx measured in CSF is proportional to the dose of Nitric Oxide inhaled during the experiment. This confirms that inhaled NO can reach the brain and affect cerebral function.

REFERENCES

1 Br J Anaesth 1997; 79:631–640[Abstract/Free Full Text]

2 Nature 2001; 409:622–626[Medline]




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[Abstract] [Full Text] [PDF]

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