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Canadian Journal of Anesthesia 50:527-528 (2003)
© Canadian Anesthesiologists' Society, 2003

Correspondence

Propofol decreases cerebral blood flow velocity in anesthetized children

Monica S. Vavilala, MD and Arthur M. Lam, MD FRCPC

Seattle, Washington

To the Editor:

In the October issue of the Journal, Karlsi et al.,1 published the results of a study examining differences in middle cerebral artery flow velocity (CBFV) in children receiving low dose vs high dose propofol infusion for urologic surgery. Examining the dose related effect of propofol on CBFV in children is important to our understanding of the differences in cerebrovascular responses between children and adults. However, no details about the age distribution of children in each of the randomized groups are presented, nor are differences in age between the two groups described. This is relevant because CBFV changes with age.2 The data appear to have been analyzed without consideration for the age-related differences in CBFV. We recognize that there are only six children in each group. Nevertheless without this information it is difficult to determine whether the difference in CBFV between the low dose and high dose propofol groups are valid for children between one and six years of age.

References

1 Karsli C, Luginbuehl I, Farrar M, Bissonnette B. Propofol decreases cerebral blood flow velocity in anesthetized children. Can J Anesth 2002; 49: 830–4.[Abstract/Free Full Text]

2 Bode H. Pediatric Applications of Transcranial Doppler Sonography. New York: Springer-Verlag; 1988: 114.


Related articles in CJA:

REPLY
Cengiz Karsli, Bruno Bissonnette, and Igor A. Luginbuehl
CJA 2003 50: 528. [Full Text]  




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